Clinical Trials

Below is a listing of Clinical Trials from the US National Cancer Institute (NCI) for breast cancer that accept men, which I update weekly.

To the right you see a button that allows you to search the trial listings of BreastCancerTrials.org for trials focused on metastatic disease and a link that allows you to do a search on that site for all the trials that accept men.

The list below was compiled by searching the NCI Clinical Trials data base with the term “breast – Male” in the “anatomic_sites” field using the published API, and restricting the results to Active trials with a status change in the last 6 months, which is hopefully the best way currently to find the newest trials (improvements coming in the database for this, I understand from the NCI’s API webpage.

This list therefore may contain the most recent trials to come on line for which men with breast cancer are eligible. Please explore the trials, and read details on their main pages on the NCI webpage, via the links provided.

This listing contains 31 trials, and was last updated on 2021-02-28

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Functional Precision Oncology for HER2 Negative or Non-amplified Metastatic or Recurrent, Unresectable Breast Cancer, FORESEE study

FORESEE: Functional Precision Oncology for Metastatic Breast Cancer: A Feasibility Trial

Phase NA

This clinical trial investigates if precision oncology may help guide treatment for patients with HER2 negative or non-amplified breast cancer that has spread to other places in the body (metastatic) or has come back (recurrent) and cannot be removed by surgery (unresectable). Precision oncology uses genetic information from a person’s tumor to help guide the choice of treatment. By looking at the genetic makeup of the cancer, researchers hope to give the right drug to achieve the best response from the treatment (targeted treatment). However, looking at the DNA of the cancer alone does not capture the complex biology of breast cancer and many factors may affect the growth of a cancer. Organoids are generated from a patient’s breast cancer biopsy sample, and are small, live versions of a patient’s cancer. Organoids retain many of the characteristics of the cancer where they came from, including its genetic composition, which makes it easier to evaluate how effective various drugs may be in treating breast cancer. Gathering biopsy samples and exposing them to multiple cancer drugs to see how well they do or do not work may help doctors in choosing a specific treatment plan that is best suited for patients with breast cancer.

This trial may be offered at the following sites in the US (please check with center directly):

Huntsman Cancer Institute / University of Utah, Salt Lake City UT |

map

Last status change to Active was on 2021-02-16.

For the complete listing see here: NCI-2020-08157

Testing MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer

A Randomized, Phase III Trial to Evaluate the Efficacy and Safety of Pembrolizumab (MK-3475) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer with > / = 1 CM Residual Invasive Cancer or Positive Lymph Nodes (ypN1mi, ypN1-3) after Neoadjuvant Chemotherapy

Phase III

This randomized phase III trial studies how well pembrolizumab works in treating patients with triple-negative breast cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

This trial may be offered at the following sites in the US (please check with center directly):

Anchorage Oncology Centre, Anchorage AK | Katmai Oncology Group, Anchorage AK | Alaska Oncology and Hematology LLC, Anchorage AK | Providence Alaska Medical Center, Anchorage AK | Fairbanks Memorial Hospital, Fairbanks AK | University of Alabama at Birmingham Cancer Center, Birmingham AL | Southern Cancer Center PC-Daphne, Daphne AL | Southern Cancer Center PC-Mobile, Mobile AL | Southern Cancer Center PC-Springhill, Mobile AL | University of South Alabama Mitchell Cancer Institute, Mobile AL | Southern Cancer Center PC-Providence, Mobile AL | Baptist Memorial Hospital and Fowler Family Cancer Center – Jonesboro, Jonesboro AR | University of Arkansas for Medical Sciences, Little Rock AR | Highlands Oncology Group, Rogers AR | Banner MD Anderson Cancer Center, Gilbert AZ | CTCA at Western Regional Medical Center, Goodyear AZ | University of Arizona Cancer Center-North Campus, Tucson AZ | Banner University Medical Center – Tucson, Tucson AZ | Tom Baker Cancer Centre, Calgary Alberta | Cross Cancer Institute, Edmonton Alberta | BCCA-Fraser Valley Cancer Centre, Surrey British Columbia | BCCA-Vancouver Cancer Centre, Vancouver British Columbia | Kaiser Permanente-Anaheim, Anaheim CA | Kaiser Permanente-Deer Valley Medical Center, Antioch CA | PCR Oncology, Arroyo Grande CA | Sutter Auburn Faith Hospital, Auburn CA | AIS Cancer Center at San Joaquin Community Hospital, Bakersfield CA | Kaiser Permanente-Baldwin Park, Baldwin Park CA | Kaiser Permanente-Bellflower, Bellflower CA | Alta Bates Summit Medical Center-Herrick Campus, Berkeley CA | Mills-Peninsula Medical Center, Burlingame CA | Community Cancer Institute, Clovis CA | City of Hope Corona, Corona CA | UC Irvine Health Cancer Center-Newport, Costa Mesa CA | City of Hope Comprehensive Cancer Center, Duarte CA | Epic Care-Dublin, Dublin CA | Bay Area Breast Surgeons Inc, Emeryville CA | Epic Care Partners in Cancer Care, Emeryville CA | Kaiser Permanente-Fontana, Fontana CA | Washington Hospital, Fremont CA | Kaiser Permanente-Fremont, Fremont CA | Kaiser Permanente-Fresno, Fresno CA | Saint Jude Medical Center, Fullerton CA | Marin Cancer Care Inc, Greenbrae CA | Kaiser Permanente – Harbor City, Harbor City CA | Kaiser Permanente-Irvine, Irvine CA | Loma Linda University Medical Center, Loma Linda CA | USC / Norris Comprehensive Cancer Center, Los Angeles CA | Kaiser Permanente-Cadillac, Los Angeles CA | Kaiser Permanente Los Angeles Medical Center, Los Angeles CA | Los Angeles County-USC Medical Center, Los Angeles CA | Contra Costa Regional Medical Center, Martinez CA | Fremont – Rideout Cancer Center, Marysville CA | City of Hope Mission Hills, Mission Hills CA | Memorial Medical Center, Modesto CA | Kaiser Permanente-Modesto, Modesto CA | Community Hospital of Monterey Peninsula, Monterey CA | Palo Alto Medical Foundation-Camino Division, Mountain View CA | Palo Alto Medical Foundation-Gynecologic Oncology, Mountain View CA | USC Norris Oncology / Hematology-Newport Beach, Newport Beach CA | Sutter Cancer Research Consortium, Novato CA | Kaiser Permanente-Oakland, Oakland CA | Alta Bates Summit Medical Center – Summit Campus, Oakland CA | Bay Area Tumor Institute, Oakland CA | Kaiser Permanente-Ontario, Ontario CA | Saint Joseph Hospital – Orange, Orange CA | UC Irvine Health / Chao Family Comprehensive Cancer Center, Orange CA | Desert Regional Medical Center, Palm Springs CA | Palo Alto Medical Foundation Health Care, Palo Alto CA | Stanford Cancer Institute Palo Alto, Palo Alto CA | Kaiser Permanente – Panorama City, Panorama City CA | Huntington Memorial Hospital, Pasadena CA | Kaiser Permanente-Redwood City, Redwood City CA | Kaiser Permanente-Richmond, Richmond CA | Kaiser Permanente-Riverside, Riverside CA | Kaiser Permanente-Roseville, Roseville CA | Sutter Roseville Medical Center, Roseville CA | University of California Davis Comprehensive Cancer Center, Sacramento CA | Kaiser Permanente – Sacramento, Sacramento CA | Kaiser Permanente Downtown Commons, Sacramento CA | Sutter Medical Center Sacramento, Sacramento CA | Salinas Valley Memorial, Salinas CA | Kaiser Permanente-San Diego Mission, San Diego CA | Kaiser Permanente-San Diego Zion, San Diego CA | California Pacific Medical Center-Pacific Campus, San Francisco CA | Kaiser Permanente-San Francisco, San Francisco CA | Stanford Cancer Center South Bay, San Jose CA | Kaiser Permanente-Santa Teresa-San Jose, San Jose CA | Kaiser Permanente San Leandro, San Leandro CA | Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo CA | Kaiser Permanente-San Marcos, San Marcos CA | Kaiser Permanente Medical Center – Santa Clara, Santa Clara CA | Palo Alto Medical Foundation-Santa Cruz, Santa Cruz CA | Mission Hope Medical Oncology – Santa Maria, Santa Maria CA | Saint Joseph Heritage Healthcare-Santa Rosa, Santa Rosa CA | Kaiser Permanente-Santa Rosa, Santa Rosa CA | City of Hope South Pasadena, South Pasadena CA | Kaiser Permanente-South San Francisco, South San Francisco CA | Kaiser Permanente-Stockton, Stockton CA | Palo Alto Medical Foundation-Sunnyvale, Sunnyvale CA | Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee CA | City of Hope Upland, Upland CA | Kaiser Permanente Medical Center-Vacaville, Vacaville CA | Sutter Solano Medical Center / Cancer Center, Vallejo CA | Kaiser Permanente-Vallejo, Vallejo CA | Kaiser Permanente-Walnut Creek, Walnut Creek CA | Presbyterian Intercommunity Hospital, Whittier CA | Kaiser Permanente-Woodland Hills, Woodland Hills CA | Rocky Mountain Cancer Centers-Aurora, Aurora CO | University of Colorado Hospital, Aurora CO | Rocky Mountain Cancer Centers-Boulder, Boulder CO | UCHealth Memorial Hospital Central, Colorado Springs CO | Memorial Hospital North, Colorado Springs CO | Penrose-Saint Francis Healthcare, Colorado Springs CO | SCL Health Saint Joseph Hospital, Denver CO | Kaiser Permanente-Franklin, Denver CO | Rocky Mountain Cancer Centers-Rose, Denver CO | Rocky Mountain Cancer Centers-Midtown, Denver CO | Porter Adventist Hospital, Denver CO | National Jewish Health-Main Campus, Denver CO | Mountain Blue Cancer Care Center – Swedish, Englewood CO | Swedish Medical Center, Englewood CO | Cancer Care and Hematology-Fort Collins, Fort Collins CO | Poudre Valley Hospital, Fort Collins CO | National Jewish Health-Western Hematology Oncology, Golden CO | Grand Valley Oncology, Grand Junction CO | North Colorado Medical Center, Greeley CO | UCHealth Greeley Hospital, Greeley CO | Good Samaritan Medical Center, Lafayette CO | Kaiser Permanente-Rock Creek, Lafayette CO | Saint Anthony Hospital, Lakewood CO | Littleton Adventist Hospital, Littleton CO | Rocky Mountain Cancer Centers-Littleton, Littleton CO | Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree CO | Kaiser Permanente-Lone Tree, Lone Tree CO | Longmont United Hospital, Longmont CO | Medical Center of the Rockies, Loveland CO | McKee Medical Center, Loveland CO | Parker Adventist Hospital, Parker CO | National Jewish Health-Northern Hematology Oncology, Thornton CO | SCL Health Lutheran Medical Center, Wheat Ridge CO | Danbury Hospital, Danbury CT | Smilow Cancer Hospital-Derby Care Center, Derby CT | Smilow Cancer Hospital Care Center-Fairfield, Fairfield CT | Greenwich Hospital, Greenwich CT | Smilow Cancer Hospital Care Center at Greenwich, Greenwich CT | Smilow Cancer Hospital Care Center at Saint Francis, Hartford CT | Hartford Hospital, Hartford CT | Midstate Medical Center, Meriden CT | The Hospital of Central Connecticut, New Britain CT | Smilow Cancer Center / Yale-New Haven Hospital, New Haven CT | Yale University, New Haven CT | Yale-New Haven Hospital North Haven Medical Center, North Haven CT | Norwalk Hospital, Norwalk CT | Smilow Cancer Hospital-Orange Care Center, Orange CT | Smilow Cancer Hospital-Torrington Care Center, Torrington CT | Smilow Cancer Hospital Care Center-Trumbull, Trumbull CT | Smilow Cancer Hospital-Waterbury Care Center, Waterbury CT | Sibley Memorial Hospital, Washington DC | Beebe South Coastal Health Campus, Frankford DE | Medical Oncology Hematology Consultants PA, Newark DE | Helen F Graham Cancer Center, Newark DE | Beebe Health Campus, Rehoboth Beach DE | TidalHealth Nanticoke / Allen Cancer Center, Seaford DE | AdventHealth Altamonte, Altamonte Springs FL | AdventHealth Celebration, Celebration FL | Morton Plant Hospital, Clearwater FL | UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables FL | Halifax Health Medical Center-Centers for Oncology, Daytona Beach FL | UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach FL | University of Florida Health Science Center – Gainesville, Gainesville FL | Baptist MD Anderson Cancer Center, Jacksonville FL | UM Sylvester Comprehensive Cancer Center at Kendall, Miami FL | University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami FL | Mount Sinai Medical Center, Miami Beach FL | Orlando Health Cancer Institute, Orlando FL | AdventHealth Orlando, Orlando FL | Sacred Heart Hospital, Pensacola FL | UM Sylvester Comprehensive Cancer Center at Plantation, Plantation FL | Tallahassee Memorial HealthCare, Tallahassee FL | Saint Joseph’s Hospital / Children’s Hospital-Tampa, Tampa FL | Cleveland Clinic-Weston, Weston FL | Phoebe Putney Memorial Hospital, Albany GA | Emory University Hospital / Winship Cancer Institute, Atlanta GA | Northside Hospital, Atlanta GA | Emory University Hospital Midtown, Atlanta GA | Emory Saint Joseph’s Hospital, Atlanta GA | Augusta Oncology Associates PC-D’Antignac, Augusta GA | Augusta Oncology Associates PC-Wheeler, Augusta GA | Dekalb Medical Center, Decatur GA | Northside Hospital – Duluth, Duluth GA | Northside Hospital – Gwinnett, Lawrenceville GA | CTCA at Southeastern Regional Medical Center, Newnan GA | Lewis Cancer and Research Pavilion at Saint Joseph’s / Candler, Savannah GA | Memorial Health University Medical Center, Savannah GA | Suburban Hematology Oncology Associates – Snellville, Snellville GA | South Georgia Medical Center / Pearlman Cancer Center, Valdosta GA | Hawaii Cancer Care – Savio, Aiea HI | Hawaii Cancer Care Inc – Waterfront Plaza, Honolulu HI | Queen’s Medical Center, Honolulu HI | Queen’s Cancer Cenrer – POB I, Honolulu HI | Kapiolani Medical Center for Women and Children, Honolulu HI | Queen’s Cancer Center – Kuakini, Honolulu HI | McFarland Clinic PC – Ames, Ames IA | Mary Greeley Medical Center, Ames IA | University of Iowa Healthcare Cancer Services Quad Cities, Bettendorf IA | McFarland Clinic PC-Boone, Boone IA | Mercy Hospital, Cedar Rapids IA | Physicians’ Clinic of Iowa PC, Cedar Rapids IA | Oncology Associates at Mercy Medical Center, Cedar Rapids IA | Medical Oncology and Hematology Associates-West Des Moines, Clive IA | Mercy Cancer Center-West Lakes, Clive IA | Greater Regional Medical Center, Creston IA | Genesis Medical Center – East Campus, Davenport IA | Iowa Cancer Specialists, Davenport IA | Genesis Cancer Care Institute, Davenport IA | Iowa Lutheran Hospital, Des Moines IA | Broadlawns Medical Center, Des Moines IA | Mercy Medical Center – Des Moines, Des Moines IA | Iowa Methodist Medical Center, Des Moines IA | Medical Oncology and Hematology Associates-Laurel, Des Moines IA | Medical Oncology and Hematology Associates-Des Moines, Des Moines IA | Trinity Regional Medical Center, Fort Dodge IA | McFarland Clinic PC-Trinity Cancer Center, Fort Dodge IA | University of Iowa / Holden Comprehensive Cancer Center, Iowa City IA | McFarland Clinic PC-Jefferson, Jefferson IA | McFarland Clinic PC-Marshalltown, Marshalltown IA | Mercy Medical Center-West Lakes, West Des Moines IA | Methodist West Hospital, West Des Moines IA | Saint Luke’s Cancer Institute – Boise, Boise ID | Saint Alphonsus Cancer Care Center-Boise, Boise ID | Saint Alphonsus Cancer Care Center-Caldwell, Caldwell ID | Kootenai Medical Center, Coeur D’Alene ID | Walter Knox Memorial Hospital, Emmett ID | Saint Luke’s Cancer Institute – Fruitland, Fruitland ID | Idaho Urologic Institute-Meridian, Meridian ID | Saint Luke’s Cancer Institute – Meridian, Meridian ID | Saint Alphonsus Medical Center-Nampa, Nampa ID | Saint Luke’s Cancer Institute – Nampa, Nampa ID | Kootenai Cancer Center, Post Falls ID | Kootenai Cancer Clinic, Sandpoint ID | Saint Luke’s Cancer Institute – Twin Falls, Twin Falls ID | Northwest Community Hospital, Arlington Heights IL | Rush – Copley Medical Center, Aurora IL | Mac Neal Hospital, Berwyn IL | Illinois CancerCare-Bloomington, Bloomington IL | Illinois CancerCare-Canton, Canton IL | SIH Cancer Institute, Carterville IL | Illinois CancerCare-Carthage, Carthage IL | Centralia Oncology Clinic, Centralia IL | Weiss Memorial Hospital, Chicago IL | Northwestern University, Chicago IL | University of Chicago Comprehensive Cancer Center, Chicago IL | Rush University Medical Center, Chicago IL | University of Illinois, Chicago IL | Mount Sinai Hospital Medical Center, Chicago IL | Carle on Vermilion, Danville IL | Northwestern Medicine Cancer Center Kishwaukee, DeKalb IL | Cancer Care Specialists of Illinois – Decatur, Decatur IL | Decatur Memorial Hospital, Decatur IL | Crossroads Cancer Center, Effingham IL | Carle Physician Group-Effingham, Effingham IL | Illinois CancerCare-Eureka, Eureka IL | NorthShore University HealthSystem-Evanston Hospital, Evanston IL | Freeport Memorial Hospital / Leonard C Ferguson Cancer Center, Freeport IL | Illinois CancerCare-Galesburg, Galesburg IL | Northwestern Medicine Cancer Center Delnor, Geneva IL | NorthShore University HealthSystem-Glenbrook Hospital, Glenview IL | NorthShore University HealthSystem-Highland Park Hospital, Highland Park IL | Joliet Oncology-Hematology Associates Limited, Joliet IL | Presence Saint Mary’s Hospital, Kankakee IL | Illinois CancerCare-Kewanee Clinic, Kewanee IL | Northwestern Medicine Lake Forest Hospital, Lake Forest IL | Illinois CancerCare-Macomb, Macomb IL | Carle Physician Group-Mattoon / Charleston, Mattoon IL | Loyola University Medical Center, Maywood IL | Good Samaritan Regional Health Center, Mount Vernon IL | UC Comprehensive Cancer Center at Silver Cross, New Lenox IL | Cancer Care Center of O’Fallon, O’Fallon IL | University of Chicago Medicine-Orland Park, Orland Park IL | Illinois CancerCare-Ottawa Clinic, Ottawa IL | Advocate Lutheran General Hospital, Park Ridge IL | Illinois CancerCare-Pekin, Pekin IL | Illinois CancerCare-Peoria, Peoria IL | Illinois CancerCare-Peru, Peru IL | Illinois CancerCare-Princeton, Princeton IL | West Suburban Medical Center, River Forest IL | SwedishAmerican Regional Cancer Center / ACT, Rockford IL | Genesis Cancer Center – Silvis, Silvis IL | Springfield Clinic, Springfield IL | Memorial Medical Center, Springfield IL | Southern Illinois University School of Medicine, Springfield IL | Carle Cancer Center, Urbana IL | Northwestern Medicine Cancer Center Warrenville, Warrenville IL | Rush-Copley Healthcare Center, Yorkville IL | IU Health North Hospital, Carmel IN | Deaconess Clinic Downtown, Evansville IN | Parkview Regional Medical Center, Fort Wayne IN | Community Cancer Center South, Indianapolis IN | Springmill Medical Center, Indianapolis IN | Community Cancer Center North, Indianapolis IN | Franciscan Health Indianapolis, Indianapolis IN | Indiana University / Melvin and Bren Simon Cancer Center, Indianapolis IN | Sidney and Lois Eskenazi Hospital, Indianapolis IN | Community Cancer Center East, Indianapolis IN | Community Howard Regional Health, Kokomo IN | Franciscan Saint Elizabeth Health – Lafayette East, Lafayette IN | Memorial Regional Cancer Center Day Road, Mishawaka IN | Chancellor Center for Oncology, Newburgh IN | Memorial Hospital of South Bend, South Bend IN | Union Hospital, Terre Haute IN | Cancer Center of Kansas – Chanute, Chanute KS | Cancer Center of Kansas – Dodge City, Dodge City KS | Cancer Center of Kansas – Fort Scott, Fort Scott KS | Central Care Cancer Center – Garden City, Garden City KS | Central Care Cancer Center – Great Bend, Great Bend KS | HaysMed University of Kansas Health System, Hays KS | University of Kansas Cancer Center-West, Kansas City KS | University of Kansas Cancer Center, Kansas City KS | Cancer Center of Kansas-Kingman, Kingman KS | Lawrence Memorial Hospital, Lawrence KS | Minimally Invasive Surgery Hospital, Lenexa KS | Kansas Institute of Medicine Cancer and Blood Center, Lenexa KS | Cancer Center of Kansas-Liberal, Liberal KS | Cancer Center of Kansas – McPherson, McPherson KS | Cancer Center of Kansas – Newton, Newton KS | Olathe Health Cancer Center, Olathe KS | University of Kansas Cancer Center-Overland Park, Overland Park KS | Menorah Medical Center, Overland Park KS | Cancer Center of Kansas – Parsons, Parsons KS | Ascension Via Christi – Pittsburg, Pittsburg KS | Cancer Center of Kansas – Pratt, Pratt KS | Salina Regional Health Center, Salina KS | Cotton O’Neil Cancer Center / Stormont Vail Health, Topeka KS | University of Kansas Health System Saint Francis Campus, Topeka KS | Cancer Center of Kansas – Wellington, Wellington KS | University of Kansas Hospital-Westwood Cancer Center, Westwood KS | Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita KS | Ascension Via Christi Hospitals Wichita, Wichita KS | Cancer Center of Kansas – Wichita, Wichita KS | Cancer Center of Kansas – Winfield, Winfield KS | Flaget Memorial Hospital, Bardstown KY | Baptist Health Corbin, Corbin KY | Baptist Health Lexington, Lexington KY | University of Kentucky / Markey Cancer Center, Lexington KY | Saint Joseph Hospital East, Lexington KY | Saint Joseph London, London KY | Baptist Health Louisville, Louisville KY | Christus Saint Frances Cabrini Hospital, Alexandria LA | Hematology / Oncology Clinic PLLC, Baton Rouge LA | Our Lady of the Lake Physicians Group – Medical Oncology, Baton Rouge LA | Medical Center of Baton Rouge, Baton Rouge LA | Ochsner Health Center-Summa, Baton Rouge LA | Mary Bird Perkins Cancer Center, Baton Rouge LA | LSU Health Baton Rouge-North Clinic, Baton Rouge LA | Ochsner High Grove, Baton Rouge LA | Louisiana Hematology Oncology Associates LLC, Baton Rouge LA | Woman’s Hospital, Baton Rouge LA | Northshore Oncology Associates-Covington, Covington LA | Ochsner Hematology Oncology North Shore – Covington (West Region), Covington LA | Oncology Center of The South Incorporated, Houma LA | Terrebonne General Medical Center, Houma LA | Ochsner Medical Center Kenner, Kenner LA | CHRISTUS Saint Patrick Hospital, Lake Charles LA | East Jefferson General Hospital, Metairie LA | University Medical Center New Orleans, New Orleans LA | Ochsner Medical Center Jefferson, New Orleans LA | Boston Medical Center, Boston MA | Lahey Hospital and Medical Center, Burlington MA | Lowell General Hospital, Lowell MA | Baystate Medical Center, Springfield MA | Winchester Hospital, Winchester MA | Anne Arundel Medical Center, Annapolis MD | Mercy Medical Center, Baltimore MD | Johns Hopkins University / Sidney Kimmel Cancer Center, Baltimore MD | Greater Baltimore Medical Center, Baltimore MD | University of Maryland / Greenebaum Cancer Center, Baltimore MD | MedStar Franklin Square Medical Center / Weinberg Cancer Institute, Baltimore MD | Saint Agnes Hospital, Baltimore MD | MedStar Good Samaritan Hospital, Baltimore MD | UM Upper Chesapeake Medical Center, Bel Air MD | FMH James M Stockman Cancer Institute, Frederick MD | Frederick Memorial Hospital, Frederick MD | TidalHealth Richard A Henson Cancer Institute, Ocean Pines MD | TidalHealth Peninsula Regional, Salisbury MD | UM Saint Joseph Medical Center, Towson MD | Harold Alfond Center for Cancer Care, Augusta ME | Eastern Maine Medical Center, Bangor ME | Waldo County General Hospital, Belfast ME | MaineHealth / SMHC Cancer Care and Blood Disorders-Biddeford, Biddeford ME | Lafayette Family Cancer Center-EMMC, Brewer ME | Maine Center for Cancer Medicine-Kennebunk, Kennebunk ME | Stephens Memorial Hospital, Norway ME | Penobscot Bay Medical Center, Rockport ME | MaineHealth / SMHC Cancer Care and Blood Disorders-Sanford, Sanford ME | Maine Center for Cancer Medicine-Scarborough, Scarborough ME | Maine Medical Partners – South Portland, South Portland ME | Maine Center for Cancer Medicine-Topsham, Topsham ME | York Hospital, York ME | Saint Joseph Mercy Hospital, Ann Arbor MI | University of Michigan Comprehensive Cancer Center, Ann Arbor MI | Bronson Battle Creek, Battle Creek MI | McLaren Cancer Institute-Bay City, Bay City MI | IHA Hematology Oncology Consultants-Brighton, Brighton MI | Saint Joseph Mercy Brighton, Brighton MI | Henry Ford Cancer Institute-Downriver, Brownstown MI | IHA Hematology Oncology Consultants-Canton, Canton MI | Saint Joseph Mercy Canton, Canton MI | Caro Cancer Center, Caro MI | Saint Joseph Mercy Chelsea, Chelsea MI | IHA Hematology Oncology Consultants-Chelsea, Chelsea MI | Newland Medical Associates-Clarkston, Clarkston MI | McLaren Cancer Institute-Clarkston, Clarkston MI | Hematology Oncology Consultants-Clarkston, Clarkston MI | Henry Ford Macomb Hospital-Clinton Township, Clinton Township MI | Beaumont Hospital – Dearborn, Dearborn MI | Henry Ford Medical Center-Fairlane, Dearborn MI | Ascension Saint John Hospital, Detroit MI | Henry Ford Hospital, Detroit MI | Wayne State University / Karmanos Cancer Institute, Detroit MI | Great Lakes Cancer Management Specialists-Doctors Park, East China MI | Michigan State University Clinical Center, East Lansing MI | Weisberg Cancer Treatment Center, Farmington Hills MI | Beaumont Hospital – Farmington Hills, Farmington Hills MI | Genesee Cancer and Blood Disease Treatment Center, Flint MI | Singh and Arora Hematology Oncology PC, Flint MI | Hurley Medical Center, Flint MI | McLaren Cancer Institute-Flint, Flint MI | Genesee Hematology Oncology PC, Flint MI | Genesys Hurley Cancer Institute, Flint MI | Mercy Health Saint Mary’s, Grand Rapids MI | Spectrum Health at Butterworth Campus, Grand Rapids MI | Great Lakes Cancer Management Specialists-Van Elslander Cancer Center, Grosse Pointe Woods MI | Academic Hematology Oncology Specialists, Grosse Pointe Woods MI | West Michigan Cancer Center, Kalamazoo MI | Bronson Methodist Hospital, Kalamazoo MI | Sparrow Hospital, Lansing MI | Mid-Michigan Physicians-Lansing, Lansing MI | McLaren-Greater Lansing, Lansing MI | McLaren Cancer Institute-Lapeer Region, Lapeer MI | Saint Mary Mercy Hospital, Livonia MI | Great Lakes Cancer Management Specialists-Macomb Medical Campus, Macomb Township MI | Saint Mary’s Oncology / Hematology Associates of Marlette, Marlette MI | UP Health System Marquette, Marquette MI | Mid-Michigan Medical Center – Midland, Midland MI | Monroe Cancer Center, Monroe MI | McLaren Cancer Institute-Macomb, Mount Clemens MI | McLaren Cancer Institute-Central Michigan, Mount Pleasant MI | Mercy Health Mercy Campus, Muskegon MI | Ascension Providence Hospitals – Novi, Novi MI | Henry Ford Medical Center-Columbus, Novi MI | McLaren Cancer Institute-Northern Michigan, Petoskey MI | Hope Cancer Center, Pontiac MI | Saint Joseph Mercy Oakland, Pontiac MI | 21st Century Oncology-Pontiac, Pontiac MI | Newland Medical Associates-Pontiac, Pontiac MI | McLaren-Port Huron, Port Huron MI | Spectrum Health Reed City Hospital, Reed City MI | Great Lakes Cancer Management Specialists-Rochester Hills, Rochester Hills MI | William Beaumont Hospital-Royal Oak, Royal Oak MI | Ascension Saint Mary’s Hospital, Saginaw MI | Oncology Hematology Associates of Saginaw Valley PC, Saginaw MI | Marie Yeager Cancer Center, Saint Joseph MI | Ascension Providence Hospitals – Southfield, Southfield MI | Munson Medical Center, Traverse City MI | William Beaumont Hospital – Troy, Troy MI | Saint John Macomb-Oakland Hospital, Warren MI | Great Lakes Cancer Management Specialists-Macomb Professional Building, Warren MI | Henry Ford West Bloomfield Hospital, West Bloomfield MI | Saint Mary’s Oncology / Hematology Associates of West Branch, West Branch MI | Metro Health Hospital, Wyoming MI | IHA Hematology Oncology Consultants-Ann Arbor, Ypsilanti MI | Sanford Joe Lueken Cancer Center, Bemidji MN | Essentia Health Saint Joseph’s Medical Center, Brainerd MN | Fairview Ridges Hospital, Burnsville MN | Minnesota Oncology – Burnsville, Burnsville MN | Mercy Hospital, Coon Rapids MN | Essentia Health – Deer River Clinic, Deer River MN | Essentia Health Saint Mary’s Medical Center, Duluth MN | Miller-Dwan Hospital, Duluth MN | Essentia Health Cancer Center, Duluth MN | Fairview Southdale Hospital, Edina MN | Unity Hospital, Fridley MN | Essentia Health Hibbing Clinic, Hibbing MN | Fairview Clinics and Surgery Center Maple Grove, Maple Grove MN | Minnesota Oncology Hematology PA-Maplewood, Maplewood MN | Saint John’s Hospital – Healtheast, Maplewood MN | Health Partners Inc, Minneapolis MN | Abbott-Northwestern Hospital, Minneapolis MN | Hennepin County Medical Center, Minneapolis MN | New Ulm Medical Center, New Ulm MN | North Memorial Medical Health Center, Robbinsdale MN | Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud MN | Park Nicollet Clinic – Saint Louis Park, Saint Louis Park MN | United Hospital, Saint Paul MN | Regions Hospital, Saint Paul MN | Essentia Health Sandstone, Sandstone MN | Saint Francis Regional Medical Center, Shakopee MN | Lakeview Hospital, Stillwater MN | Essentia Health Virginia Clinic, Virginia MN | Ridgeview Medical Center, Waconia MN | Rice Memorial Hospital, Willmar MN | Minnesota Oncology Hematology PA-Woodbury, Woodbury MN | Fairview Lakes Medical Center, Wyoming MN | Saint Louis Cancer and Breast Institute-Ballwin, Ballwin MO | Central Care Cancer Center – Bolivar, Bolivar MO | Southeast Cancer Center, Cape Girardeau MO | Saint Francis Medical Center, Cape Girardeau MO | Centerpoint Medical Center LLC, Independence MO | Capital Region Southwest Campus, Jefferson City MO | Freeman Health System, Joplin MO | Research Medical Center, Kansas City MO | University of Kansas Cancer Center – North, Kansas City MO | Truman Medical Centers, Kansas City MO | University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City MO | Heartland Regional Medical Center, Saint Joseph MO | Saint Louis Cancer and Breast Institute-South City, Saint Louis MO | Mercy Hospital Saint Louis, Saint Louis MO | Missouri Baptist Medical Center, Saint Louis MO | CoxHealth South Hospital, Springfield MO | Baptist Memorial Hospital and Cancer Center-Golden Triangle, Columbus MS | Baptist Cancer Center-Grenada, Grenada MS | Baptist Memorial Hospital and Cancer Center-Union County, New Albany MS | Baptist Memorial Hospital and Cancer Center-Oxford, Oxford MS | Singing River Hospital, Pascagoula MS | Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven MS | Community Hospital of Anaconda, Anaconda MT | Billings Clinic Cancer Center, Billings MT | Bozeman Deaconess Hospital, Bozeman MT | Saint James Community Hospital and Cancer Treatment Center, Butte MT | Great Falls Clinic, Great Falls MT | Benefis Healthcare- Sletten Cancer Institute, Great Falls MT | Saint Peter’s Community Hospital, Helena MT | Kalispell Regional Medical Center, Kalispell MT | Community Medical Hospital, Missoula MT | Atrium Health Stanly / LCI-Albemarle, Albemarle NC | Randolph Hospital, Asheboro NC | Mission Hospital, Asheville NC | Hope Women’s Cancer Centers-Asheville, Asheville NC | Messino Cancer Centers, Asheville NC | Cone Health Cancer Center at Alamance Regional, Burlington NC | UNC Lineberger Comprehensive Cancer Center, Chapel Hill NC | Oncology Specialists of Charlotte, Charlotte NC | Carolinas Medical Center / Levine Cancer Institute, Charlotte NC | Novant Health Presbyterian Medical Center, Charlotte NC | Atrium Health Pineville / LCI-Pineville, Charlotte NC | Southeastern Medical Oncology Center-Clinton, Clinton NC | Atrium Health Cabarrus / LCI-Concord, Concord NC | Duke University Medical Center, Durham NC | Southeastern Medical Oncology Center-Goldsboro, Goldsboro NC | Cone Health Cancer Center, Greensboro NC | Margaret R Pardee Memorial Hospital, Hendersonville NC | Southern Oncology Specialists-Huntersville, Huntersville NC | Novant Health Cancer Institute – Huntersville, Huntersville NC | Southeastern Medical Oncology Center-Jacksonville, Jacksonville NC | Vidant Oncology-Kenansville, Kenansville NC | Novant Health Cancer Institute – Kernersville, Kernersville NC | Vidant Oncology-Kinston, Kinston NC | Novant Health Cancer Specialists-Matthews, Matthews NC | Cone Heath Cancer Center at Mebane, Mebane NC | Novant Health Cancer Institute – Mooresville, Mooresville NC | Novant Health Cancer Institute – Mount Airy, Mount Airy NC | FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst NC | Annie Penn Memorial Hospital, Reidsville NC | Vidant Oncology-Richlands, Richlands NC | Novant Health Cancer Institute – Statesville, Stateville NC | Novant Health Cancer Institute – Thomasville, Thomasville NC | Novant Health Cancer Institute – Wilkesboro, Wilkesboro NC | Wake Forest University Health Sciences, Winston-Salem NC | Novant Health Forsyth Medical Center, Winston-Salem NC | Novant Health Oncology Specialists, Winston-Salem NC | Sanford Bismarck Medical Center, Bismarck ND | Essentia Health Cancer Center-South University Clinic, Fargo ND | Sanford Broadway Medical Center, Fargo ND | Sanford Roger Maris Cancer Center, Fargo ND | CHI Health Saint Francis, Grand Island NE | CHI Health Good Samaritan, Kearney NE | University of Nebraska Medical Center, Omaha NE | Alegent Health Bergan Mercy Medical Center, Omaha NE | Alegent Health Immanuel Medical Center, Omaha NE | Alegent Health Lakeside Hospital, Omaha NE | Nebraska Methodist Hospital, Omaha NE | New Hampshire Oncology Hematology PA-Concord, Concord NH | Dartmouth Hitchcock Medical Center, Lebanon NH | Norris Cotton Cancer Center-Manchester, Manchester NH | Solinsky Center for Cancer Care, Manchester NH | Saint Joseph Hospital, Nashua NH | Norris Cotton Cancer Center-Nashua, Nashua NH | Hackensack University Medical Center, Hackensack NJ | The Cancer Institute of New Jersey Hamilton, Hamilton NJ | Saint Barnabas Medical Center, Livingston NJ | Monmouth Medical Center, Long Branch NJ | Virtua Memorial, Mount Holly NJ | Jersey Shore Medical Center, Neptune NJ | Rutgers Cancer Institute of New Jersey, New Brunswick NJ | Newark Beth Israel Medical Center, Newark NJ | The Valley Hospital-Luckow Pavilion, Paramus NJ | Riverview Medical Center / Booker Cancer Center, Red Bank NJ | Valley Hospital, Ridgewood NJ | Robert Wood Johnson University Hospital Somerset, Somerville NJ | Sparta Cancer Treatment Center, Sparta NJ | Virtua Voorhees, Voorhees NJ | MD Anderson Cancer Center at Cooper-Voorhees, Voorhees NJ | Valley Health System-Hematology / Oncology, Westwood NJ | University of New Mexico Cancer Center, Albuquerque NM | New Mexico Oncology Hematology Consultants, Albuquerque NM | Lovelace Medical Center-Saint Joseph Square, Albuquerque NM | Presbyterian Kaseman Hospital, Albuquerque NM | Memorial Medical Center – Las Cruces, Las Cruces NM | Presbyterian Rust Medical Center / Jorgensen Cancer Center, Rio Rancho NM | Christus Saint Vincent Regional Cancer Center, Santa Fe NM | OptumCare Cancer Care at Seven Hills, Henderson NV | OptumCare Cancer Care at MountainView, Las Vegas NV | OptumCare Cancer Care at Fort Apache, Las Vegas NV | OptumCare Cancer Care at Oakey, Las Vegas NV | Saint Mary’s Regional Medical Center, Reno NV | Renown Regional Medical Center, Reno NV | Montefiore Medical Center – Moses Campus, Bronx NY | Montefiore Medical Center-Einstein Campus, Bronx NY | Montefiore Medical Center-Weiler Hospital, Bronx NY | New York-Presbyterian / Brooklyn Methodist Hospital, Brooklyn NY | Roswell Park Cancer Institute, Buffalo NY | Arnot Ogden Medical Center / Falck Cancer Center, Elmira NY | Garnet Health Medical Center, Middletown NY | NYU Winthrop Hospital, Mineola NY | NYP / Columbia University Medical Center / Herbert Irving Comprehensive Cancer Center, New York NY | Mount Sinai West, New York NY | Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York NY | Mount Sinai Union Square, New York NY | Mount Sinai Hospital, New York NY | NYP / Weill Cornell Medical Center, New York NY | University of Rochester, Rochester NY | Staten Island University Hospital, Staten Island NY | Stony Brook University Medical Center, Stony Brook NY | State University of New York Upstate Medical University, Syracuse NY | Dickstein Cancer Treatment Center, White Plains NY | The Moncton Hospital, Moncton New Brunswick | Atlantic Health Sciences Corporation-Saint John Regional Hospital, Saint John New Brunswick | Summa Health System – Akron Campus, Akron OH | UHHS-Chagrin Highlands Medical Center, Beachwood OH | Cleveland Clinic Cancer Center Beachwood, Beachwood OH | Indu and Raj Soin Medical Center, Beavercreek OH | Strecker Cancer Center-Belpre, Belpre OH | Mercy Medical Center, Canton OH | Aultman Health Foundation, Canton OH | Dayton Physicians LLC-Miami Valley South, Centerville OH | Adena Regional Medical Center, Chillicothe OH | Good Samaritan Hospital – Cincinnati, Cincinnati OH | The Christ Hospital, Cincinnati OH | MetroHealth Medical Center, Cleveland OH | Case Western Reserve University, Cleveland OH | Cleveland Clinic Foundation, Cleveland OH | Cleveland Clinic Cancer Center / Fairview Hospital, Cleveland OH | Riverside Methodist Hospital, Columbus OH | Grant Medical Center, Columbus OH | Ohio State University Comprehensive Cancer Center, Columbus OH | Mount Carmel Health Center West, Columbus OH | The Mark H Zangmeister Center, Columbus OH | Mount Carmel East Hospital, Columbus OH | Doctors Hospital, Columbus OH | Columbus Oncology and Hematology Associates Inc, Columbus OH | Delaware Health Center-Grady Cancer Center, Delaware OH | Grady Memorial Hospital, Delaware OH | Mercy Cancer Center-Elyria, Elyria OH | Dayton Physicians LLC-Atrium, Franklin OH | Cleveland Clinic Cancer Center Independence, Independence OH | Kettering Medical Center, Kettering OH | Saint Rita’s Medical Center, Lima OH | OhioHealth Mansfield Hospital, Mansfield OH | Cleveland Clinic Cancer Center Mansfield, Mansfield OH | Marietta Memorial Hospital, Marietta OH | OhioHealth Marion General Hospital, Marion OH | Hillcrest Hospital Cancer Center, Mayfield Heights OH | UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor OH | UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights OH | Knox Community Hospital, Mount Vernon OH | Licking Memorial Hospital, Newark OH | University Hospitals Parma Medical Center, Parma OH | Mercy Health Perrysburg Cancer Center, Perrysburg OH | Southern Ohio Medical Center, Portsmouth OH | UH Seidman Cancer Center at Firelands Regional Medical Center, Sandusky OH | North Coast Cancer Care, Sandusky OH | Springfield Regional Medical Center, Springfield OH | Trinity’s Tony Teramana Cancer Center, Steubenville OH | Cleveland Clinic Cancer Center Strongsville, Strongsville OH | ProMedica Flower Hospital, Sylvania OH | ProMedica Toledo Hospital / Russell J Ebeid Children’s Hospital, Toledo OH | Mercy Health – Saint Anne Hospital, Toledo OH | Toledo Clinic Cancer Centers-Toledo, Toledo OH | University Hospitals Sharon Health Center, Wadsworth OH | South Pointe Hospital, Warrensville Heights OH | Saint Ann’s Hospital, Westerville OH | UH Seidman Cancer Center at Saint John Medical Center, Westlake OH | UHHS-Westlake Medical Center, Westlake OH | Cleveland Clinic Wooster Family Health and Surgery Center, Wooster OH | Genesis Healthcare System Cancer Care Center, Zanesville OH | Cancer Centers of Southwest Oklahoma Research, Lawton OK | Integris Cancer Institute of Oklahoma, Oklahoma City OK | Mercy Hospital Oklahoma City, Oklahoma City OK | University of Oklahoma Health Sciences Center, Oklahoma City OK | Cancer Treatment Centers of America, Tulsa OK | Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa OK | Saint Alphonsus Medical Center-Baker City, Baker City OR | Providence Cancer Institute Clackamas Clinic, Clackamas OR | Good Samaritan Hospital, Corvallis OR | Three Rivers Community Hospital, Grants Pass OR | Legacy Mount Hood Medical Center, Gresham OR | Rogue Valley Medical Center, Medford OR | Providence Newberg Medical Center, Newberg OR | Saint Alphonsus Medical Center-Ontario, Ontario OR | Kaiser Permanente Northwest, Portland OR | Oregon Health and Science University, Portland OR | Legacy Good Samaritan Hospital and Medical Center, Portland OR | Providence Saint Vincent Medical Center, Portland OR | Providence Portland Medical Center, Portland OR | Legacy Meridian Park Hospital, Tualatin OR | Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton Ontario | Grand River Regional Cancer Centre at Grand River Hospital, Kitchener Ontario | London Regional Cancer Program, London Ontario | Stronach Regional Health Centre at Southlake, Newmarket Ontario | Algoma District Cancer Program Sault Area Hospital, Sault Ste Marie Ontario | Odette Cancer Centre- Sunnybrook Health Sciences Centre, Toronto Ontario | Humber River Hospital, Toronto Ontario | Abington Memorial Hospital, Abington PA | Lehigh Valley Hospital-Cedar Crest, Allentown PA | Lehigh Valley Hospital – Muhlenberg, Bethlehem PA | Bryn Mawr Hospital, Bryn Mawr PA | Doylestown Hospital, Doylestown PA | Saint Vincent Hospital, Erie PA | UPMC Pinnacle Cancer Center / Community Osteopathic Campus, Harrisburg PA | Jefferson Hospital, Jefferson Hills PA | Riddle Memorial Hospital, Media PA | Forbes Hospital, Monroeville PA | Paoli Memorial Hospital, Paoli PA | Aria Health-Torresdale Campus, Philadelphia PA | Fox Chase Cancer Center, Philadelphia PA | Thomas Jefferson University Hospital, Philadelphia PA | Eastern Regional Medical Center, Philadelphia PA | West Penn Hospital, Pittsburgh PA | University of Pittsburgh Cancer Institute (UPCI), Pittsburgh PA | Allegheny General Hospital, Pittsburgh PA | Chester County Hospital, West Chester PA | Reading Hospital, West Reading PA | Wexford Health and Wellness Pavilion, Wexford PA | UPMC Susquehanna, Williamsport PA | Abington Memorial Hospital-Asplundh Cancer Pavilion, Willow Grove PA | Lankenau Medical Center, Wynnewood PA | UPMC Memorial, York PA | Cancer Center-Metro Medical Center Bayamon, Bayamon PR | Doctors Cancer Center, Manati PR | San Juan Community Oncology Group, San Juan PR | San Juan City Hospital, San Juan PR | Hopital de la Cite-de-la-Sante, Laval Quebec | Hopital Du Sacre-Coeur de Montreal, Montreal Quebec | The Research Institute of the McGill University Health Centre (MUHC), Montreal Quebec | Jewish General Hospital, Montreal Quebec | CHU de Quebec-Hopital du Saint-Sacrement (HSS), Quebec City Quebec | AnMed Health Cancer Center, Anderson SC | Prisma Health Cancer Institute – Spartanburg, Boiling Springs SC | Medical University of South Carolina, Charleston SC | Prisma Health Cancer Institute – Laurens, Clinton SC | Prisma Health Cancer Institute – Easley, Easley SC | McLeod Regional Medical Center, Florence SC | Gibbs Cancer Center-Gaffney, Gaffney SC | Tidelands Georgetown Memorial Hospital, Georgetown SC | Prisma Health Cancer Institute – Butternut, Greenville SC | Saint Francis Hospital, Greenville SC | Prisma Health Cancer Institute – Faris, Greenville SC | Saint Francis Cancer Center, Greenville SC | Prisma Health Cancer Institute – Eastside, Greenville SC | Self Regional Healthcare, Greenwood SC | Prisma Health Cancer Institute – Greer, Greer SC | Gibbs Cancer Center-Pelham, Greer SC | South Carolina Cancer Specialists PC, Hilton Head Island SC | Levine Cancer Institute-Rock Hill, Rock Hill SC | Prisma Health Cancer Institute – Seneca, Seneca SC | Spartanburg Medical Center, Spartanburg SC | MGC Hematology Oncology-Union, Union SC | Lexington Medical Center, West Columbia SC | Avera Cancer Institute at Pierre, Pierre SD | Rapid City Regional Hospital, Rapid City SD | Sanford Cancer Center Oncology Clinic, Sioux Falls SD | Sanford USD Medical Center – Sioux Falls, Sioux Falls SD | Avera Cancer Institute, Sioux Falls SD | Allan Blair Cancer Centre, Regina Saskatchewan | Baptist Memorial Hospital and Cancer Center-Collierville, Collierville TN | Vanderbilt-Ingram Cancer Center Cool Springs, Franklin TN | Regional Cancer Center at Indian Path Community Hospital, Kingsport TN | Thompson Cancer Survival Center – West, Knoxville TN | Thompson Cancer Survival Center, Knoxville TN | Thompson Oncology Group-Lenoir City, Lenoir City TN | Thompson Oncology Group-Maryville, Maryville TN | Baptist Memorial Hospital and Cancer Center-Memphis, Memphis TN | Vanderbilt University / Ingram Cancer Center, Nashville TN | Vanderbilt Breast Center at One Hundred Oaks, Nashville TN | Thompson Oncology Group-Oak Ridge, Oak Ridge TN | The Don and Sybil Harrington Cancer Center, Amarillo TX | Austin Cancer Centers-Saint David’s, Austin TX | Dell Seton Medical Center at The University of Texas, Austin TX | Austin Cancer Centers-Central Austin, Austin TX | Houston Methodist San Jacinto Hospital, Baytown TX | MD Anderson in The Woodlands, Conroe TX | M D Anderson Cancer Center, Houston TX | Houston Methodist Hospital, Houston TX | Methodist Willowbrook Hospital, Houston TX | Lyndon Baines Johnson General Hospital, Houston TX | Ben Taub General Hospital, Houston TX | Baylor College of Medicine / Dan L Duncan Comprehensive Cancer Center, Houston TX | Houston Methodist West Hospital, Houston TX | MD Anderson West Houston, Houston TX | MD Anderson League City, League City TX | Houston Methodist Saint John Hospital, Nassau Bay TX | Houston Methodist Sugar Land Hospital, Sugar Land TX | MD Anderson in Sugar Land, Sugar Land TX | Houston Methodist The Woodlands Hospital, The Woodlands TX | Farmington Health Center, Farmington UT | University of Utah Sugarhouse Health Center, Salt Lake City UT | Huntsman Cancer Institute / University of Utah, Salt Lake City UT | South Jordan Health Center, South Jordan UT | Wellmont Medical Associates-Bristol, Bristol VA | Inova Schar Cancer Institute, Fairfax VA | Augusta Health Center for Cancer and Blood Disorders, Fishersville VA | Centra Lynchburg Hematology-Oncology Clinic Inc, Lynchburg VA | Bon Secours Memorial Regional Medical Center, Mechanicsville VA | Bon Secours Saint Francis Medical Center, Midlothian VA | Peninsula Cancer Institute-Newport News, Newport News VA | Southwest VA Regional Cancer Center, Norton VA | Virginia Cancer Institute, Richmond VA | Virginia Commonwealth University / Massey Cancer Center, Richmond VA | Bon Secours Saint Mary’s Hospital, Richmond VA | VCU Massey Cancer Center at Stony Point, Richmond VA | VCU Community Memorial Health Center, South Hill VA | Peninsula Cancer Institute-Cancer Specialists of Tidewater, Virginia Beach VA | Shenandoah Oncology PC, Winchester VA | Norris Cotton Cancer Center-North, Saint Johnsbury VT | Providence Regional Cancer System-Aberdeen, Aberdeen WA | Overlake Medical Center, Bellevue WA | PeaceHealth Saint Joseph Medical Center, Bellingham WA | Harrison HealthPartners Hematology and Oncology-Bremerton, Bremerton WA | Providence Regional Cancer System-Centralia, Centralia WA | Swedish Cancer Institute-Edmonds, Edmonds WA | Kadlec Clinic Hematology and Oncology, Kennewick WA | Seattle Cancer Care Alliance at EvergreenHealth, Kirkland WA | Providence Regional Cancer System-Lacey, Lacey WA | PeaceHealth Saint John Medical Center, Longview WA | Skagit Valley Hospital, Mount Vernon WA | Skagit Valley Hospital Regional Cancer Care Center, Mount Vernon WA | Jefferson Healthcare, Port Townsend WA | Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo WA | Seattle Cancer Care Alliance at Northwest Hospital, Seattle WA | Swedish Medical Center-First Hill, Seattle WA | Seattle Cancer Care Alliance, Seattle WA | Fred Hutchinson Cancer Research Center, Seattle WA | University of Washington Medical Center – Montlake, Seattle WA | Spokane Valley Cancer Center-Mayfair, Spokane WA | PeaceHealth Southwest Medical Center, Vancouver WA | Legacy Salmon Creek Hospital, Vancouver WA | Legacy Cancer Institute Medical Oncology and Day Treatment, Vancouver WA | North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima WA | Langlade Hospital and Cancer Center, Antigo WI | Ascension Saint Elizabeth Hospital, Appleton WI | ThedaCare Regional Cancer Center, Appleton WI | Duluth Clinic Ashland, Ashland WI | Ascension Southeast Wisconsin Hospital – Elmbrook Campus, Brookfield WI | Aurora Cancer Care-Southern Lakes VLCC, Burlington WI | Ascension Calumet Hospital, Chilton WI | Aurora Health Center-Fond du Lac, Fond Du Lac WI | Ascension Saint Francis – Reiman Cancer Center, Franklin WI | Aurora Health Care Germantown Health Center, Germantown WI | Aurora Cancer Care-Grafton, Grafton WI | Saint Vincent Hospital Cancer Center at Saint Mary’s, Green Bay WI | Aurora BayCare Medical Center, Green Bay WI | Saint Vincent Hospital Cancer Center Green Bay, Green Bay WI | UW Cancer Center Johnson Creek, Johnson Creek WI | Aurora Cancer Care-Kenosha South, Kenosha WI | Gundersen Lutheran Medical Center, La Crosse WI | University of Wisconsin Hospital and Clinics, Madison WI | Aurora Bay Area Medical Group-Marinette, Marinette WI | Saint Vincent Hospital Cancer Center at Marinette, Marinette WI | Aspirus Medford Hospital, Medford WI | Ascension Columbia Saint Mary’s Hospital Ozaukee, Mequon WI | Aurora Sinai Medical Center, Milwaukee WI | Ascension Columbia Saint Mary’s Hospital – Milwaukee, Milwaukee WI | Aurora Saint Luke’s Medical Center, Milwaukee WI | Aurora Cancer Care-Milwaukee, Milwaukee WI | ProHealth D N Greenwald Center, Mukwonago WI | Cancer Center of Western Wisconsin, New Richmond WI | ProHealth Oconomowoc Memorial Hospital, Oconomowoc WI | Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls WI | Vince Lombardi Cancer Clinic – Oshkosh, Oshkosh WI | Ascension Mercy Hospital, Oshkosh WI | Ascension All Saints Hospital, Racine WI | Aurora Cancer Care-Racine, Racine WI | Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan WI | Ascension Saint Michael’s Hospital, Stevens Point WI | Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay WI | Aurora Medical Center in Summit, Summit WI | Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers WI | UW Cancer Center at ProHealth Care, Waukesha WI | ProHealth Waukesha Memorial Hospital, Waukesha WI | Aspirus Regional Cancer Center, Wausau WI | Aurora Cancer Care-Milwaukee West, Wauwatosa WI | Ascension Medical Group Southeast Wisconsin – Mayfair Road, Wauwatosa WI | Aurora West Allis Medical Center, West Allis WI | Aspirus Cancer Care – Wisconsin Rapids, Wisconsin Rapids WI | Edwards Comprehensive Cancer Center, Huntington WV | Billings Clinic-Cody, Cody WY |

Last status change to Active was on 2021-02-05.

For the complete listing see here: NCI-2016-01595

Concurrent WOKVAC Vaccination, Chemotherapy, and HER2-Targeted Monoclonal Antibody Therapy before Surgery for the Treatment of Patients with Breast Cancer

A Phase II Study of Concurrent WOKVAC Vaccination with Neoadjuvant Chemotherapy and HER2-Targeted Monoclonal Antibody Therapy

Phase II

This phase II trial studies the immunologic response and side effects of using the WOKVAC vaccine in combination with chemotherapy and HER2-targeted monoclonal antibody therapy before surgery in treating patients with breast cancer. Vaccines like WOKVAC are made from tumor-associated antigens which may help the body build an effective immune response to kill tumor cells. Chemotherapy drugs, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Trastuzumab and pertuzumab are forms of targeted therapy because they work by attaching themselves to specific molecules (receptors) on the surface of tumor cells, known as HER2 receptors. When trastuzumab and pertuzumab attach to HER2 receptors, the signals that tell the cells to grow are blocked and the tumor cell may be marked for destruction by the body’s immune system. Giving the WOKVAC vaccine at the same time (concurrently) with paclitaxel, trastuzumab, and pertuzumab before surgery may kill more tumor cells.

This trial may be offered at the following sites in the US (please check with center directly):

Fred Hutch / University of Washington Cancer Consortium, Seattle WA |

map

Last status change to Active was on 2021-01-28.

For the complete listing see here: NCI-2020-01662

T-DM1 and Tucatinib Compared with T-DM1 Alone in Preventing Relapses in People with High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial

The CompassHER2 Trials (Comprehensive Use of Pathologic Response Assessment to Optimize Therapy in HER2-Positive Breast Cancer): CompassHER2 Residual Disease (RD), A Double-Blinded, Phase III Randomized Trial of T-DM1 and Placebo Compared with T-DM1 and Tucatinib

Phase III

This phase III trial compares the effect of usual treatment with trastuzumab emtansine (T-DM1) alone vs. T-DM1 in combination with tucatinib. T-DM1 is a monoclonal antibody, called trastuzumab, linked to a chemotherapy drug, called DM1. Trastuzumab is a form of targeted therapy because it attaches to specific molecules (receptors) on the surface of cancer cells, known as HER2 receptors, and delivers DM1 to kill them. Tucatinib blocks HER2, which may help keep cancer cells from growing and may kill them. Giving T-DM1 in combination with tucatinib may work better in preventing breast cancer from relapsing in patients with HER2 positive breast cancer compared to T-DM1 alone.

This trial may be offered at the following sites in the US (please check with center directly):

Anchorage Oncology Centre, Anchorage AK | Alaska Breast Care and Surgery LLC, Anchorage AK | Katmai Oncology Group, Anchorage AK | Providence Alaska Medical Center, Anchorage AK | Anchorage Radiation Therapy Center, Anchorage AK | Alaska Oncology and Hematology LLC, Anchorage AK | Alaska Women’s Cancer Care, Anchorage AK | Anchorage Associates in Radiation Medicine, Anchorage AK | Mercy Hospital Fort Smith, Ft. Smith AR | CHI Saint Vincent Cancer Center Hot Springs, Hot Springs AR | Kingman Regional Medical Center, Kingman AZ | Cancer Center at Saint Joseph’s, Phoenix AZ | PCR Oncology, Arroyo Grande CA | Mission Hope Medical Oncology – Arroyo Grande, Arroyo Grande CA | Sutter Auburn Faith Hospital, Auburn CA | Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn CA | Alta Bates Summit Medical Center-Herrick Campus, Berkeley CA | Providence Saint Joseph Medical Center / Disney Family Cancer Center, Burbank CA | Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park CA | Eden Hospital Medical Center, Castro Valley CA | UC Irvine Health Cancer Center-Newport, Costa Mesa CA | Sutter Davis Hospital, Davis CA | Palo Alto Medical Foundation-Fremont, Fremont CA | Memorial Medical Center, Modesto CA | Palo Alto Medical Foundation-Gynecologic Oncology, Mountain View CA | Palo Alto Medical Foundation-Camino Division, Mountain View CA | UC Irvine Health / Chao Family Comprehensive Cancer Center, Orange CA | Palo Alto Medical Foundation Health Care, Palo Alto CA | Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville CA | Sutter Roseville Medical Center, Roseville CA | Sutter Medical Center Sacramento, Sacramento CA | California Pacific Medical Center-Pacific Campus, San Francisco CA | Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo CA | Palo Alto Medical Foundation-Santa Cruz, Santa Cruz CA | Mission Hope Medical Oncology – Santa Maria, Santa Maria CA | Sutter Pacific Medical Foundation, Santa Rosa CA | Palo Alto Medical Foundation-Sunnyvale, Sunnyvale CA | Sutter Cancer Centers Radiation Oncology Services-Vacaville, Vacaville CA | Sutter Solano Medical Center / Cancer Center, Vallejo CA | Rocky Mountain Cancer Centers-Penrose, Colorado Springs CO | Penrose-Saint Francis Healthcare, Colorado Springs CO | Porter Adventist Hospital, Denver CO | Mercy Medical Center, Durango CO | Southwest Oncology PC, Durango CO | Saint Anthony Hospital, Lakewood CO | Littleton Adventist Hospital, Littleton CO | Longmont United Hospital, Longmont CO | Rocky Mountain Cancer Centers-Longmont, Longmont CO | Parker Adventist Hospital, Parker CO | Saint Mary Corwin Medical Center, Pueblo CO | Danbury Hospital, Danbury CT | Norwalk Hospital, Norwalk CT | Kaiser Permanente-Capitol Hill Medical Center, Washington DC | Holy Cross Hospital, Fort Lauderdale FL | Memorial Regional Hospital / Joe DiMaggio Children’s Hospital, Hollywood FL | Memorial Hospital West, Pembroke Pines FL | Sacred Heart Hospital, Pensacola FL | McFarland Clinic PC – Ames, Ames IA | Mary Greeley Medical Center, Ames IA | McFarland Clinic PC-Boone, Boone IA | Mercy Cancer Center-West Lakes, Clive IA | Medical Oncology and Hematology Associates-West Des Moines, Clive IA | Alegent Health Mercy Hospital, Council Bluffs IA | Greater Regional Medical Center, Creston IA | Iowa Cancer Specialists, Davenport IA | Genesis Cancer Care Institute, Davenport IA | Genesis Medical Center – East Campus, Davenport IA | Medical Oncology and Hematology Associates-Laurel, Des Moines IA | Mercy Medical Center – Des Moines, Des Moines IA | McFarland Clinic PC-Trinity Cancer Center, Fort Dodge IA | McFarland Clinic PC-Jefferson, Jefferson IA | McFarland Clinic PC-Marshalltown, Marshalltown IA | Mercy Medical Center-West Lakes, West Des Moines IA | Saint Luke’s Cancer Institute – Boise, Boise ID | Saint Alphonsus Cancer Care Center-Boise, Boise ID | Saint Alphonsus Cancer Care Center-Caldwell, Caldwell ID | Kootenai Medical Center, Coeur D’Alene ID | Walter Knox Memorial Hospital, Emmett ID | Saint Luke’s Cancer Institute – Fruitland, Fruitland ID | Saint Luke’s Cancer Institute – Meridian, Meridian ID | Idaho Urologic Institute-Meridian, Meridian ID | Saint Alphonsus Medical Center-Nampa, Nampa ID | Saint Luke’s Cancer Institute – Nampa, Nampa ID | Kootenai Cancer Center, Post Falls ID | Kootenai Cancer Clinic, Sandpoint ID | Saint Luke’s Cancer Institute – Twin Falls, Twin Falls ID | Illinois CancerCare-Bloomington, Bloomington IL | Illinois CancerCare-Canton, Canton IL | Memorial Hospital of Carbondale, Carbondale IL | SIH Cancer Institute, Carterville IL | Illinois CancerCare-Carthage, Carthage IL | Centralia Oncology Clinic, Centralia IL | University of Illinois, Chicago IL | Decatur Memorial Hospital, Decatur IL | Cancer Care Specialists of Illinois – Decatur, Decatur IL | Illinois CancerCare-Dixon, Dixon IL | Crossroads Cancer Center, Effingham IL | Illinois CancerCare-Eureka, Eureka IL | Illinois CancerCare-Galesburg, Galesburg IL | Western Illinois Cancer Treatment Center, Galesburg IL | Ingalls Memorial Hospital, Harvey IL | Illinois CancerCare-Kewanee Clinic, Kewanee IL | Illinois CancerCare-Macomb, Macomb IL | Good Samaritan Regional Health Center, Mount Vernon IL | Cancer Care Center of O’Fallon, O’Fallon IL | Illinois CancerCare-Ottawa Clinic, Ottawa IL | Illinois CancerCare-Pekin, Pekin IL | OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center, Pekin IL | Methodist Medical Center of Illinois, Peoria IL | OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria IL | Illinois CancerCare-Peoria, Peoria IL | OSF Saint Francis Medical Center, Peoria IL | Illinois CancerCare-Peru, Peru IL | Valley Radiation Oncology, Peru IL | Illinois CancerCare-Princeton, Princeton IL | OSF Saint Anthony Medical Center, Rockford IL | Genesis Cancer Center – Silvis, Silvis IL | Springfield Clinic, Springfield IL | Southern Illinois University School of Medicine, Springfield IL | Memorial Medical Center, Springfield IL | Franciscan Health Indianapolis, Indianapolis IN | Franciscan Saint Elizabeth Health – Lafayette East, Lafayette IN | Woodland Cancer Care Center, Michigan City IN | Franciscan Health Mooresville, Mooresville IN | Flaget Memorial Hospital, Bardstown KY | Commonwealth Cancer Center-Corbin, Corbin KY | Saint Joseph Hospital East, Lexington KY | Saint Joseph Radiation Oncology Resource Center, Lexington KY | Saint Joseph London, London KY | Saints Mary and Elizabeth Hospital, Louisville KY | Jewish Hospital, Louisville KY | Jewish Hospital Medical Center Northeast, Louisville KY | Jewish Hospital Medical Center South, Shepherdsville KY | Kaiser Permanente-Woodlawn Medical Center, Baltimore MD | Kaiser Permanente-Gaithersburg Medical Center, Gaithersburg MD | Kaiser Permanente – Kensington Medical Center, Kensington MD | Kaiser Permanente – Largo Medical Center, Largo MD | Hickman Cancer Center, Adrian MI | Saint Joseph Mercy Hospital, Ann Arbor MI | Saint Joseph Mercy Brighton, Brighton MI | IHA Hematology Oncology Consultants-Brighton, Brighton MI | Saint Joseph Mercy Canton, Canton MI | IHA Hematology Oncology Consultants-Canton, Canton MI | Caro Cancer Center, Caro MI | Saint Joseph Mercy Chelsea, Chelsea MI | IHA Hematology Oncology Consultants-Chelsea, Chelsea MI | Newland Medical Associates-Clarkston, Clarkston MI | Hematology Oncology Consultants-Clarkston, Clarkston MI | Ascension Saint John Hospital, Detroit MI | Great Lakes Cancer Management Specialists-Doctors Park, East China MI | Genesee Hematology Oncology PC, Flint MI | Genesys Hurley Cancer Institute, Flint MI | Hurley Medical Center, Flint MI | Genesee Cancer and Blood Disease Treatment Center, Flint MI | Great Lakes Cancer Management Specialists-Van Elslander Cancer Center, Grosse Pointe Woods MI | Michigan Breast Specialists-Grosse Pointe Woods, Grosse Pointe Woods MI | Academic Hematology Oncology Specialists, Grosse Pointe Woods MI | Sparrow Hospital, Lansing MI | Hope Cancer Clinic, Livonia MI | Saint Mary Mercy Hospital, Livonia MI | Great Lakes Cancer Management Specialists-Macomb Medical Campus, Macomb Township MI | Michigan Breast Specialists-Macomb Township, Macomb Township MI | Saint Mary’s Oncology / Hematology Associates of Marlette, Marlette MI | Toledo Clinic Cancer Centers-Monroe, Monroe MI | Newland Medical Associates-Pontiac, Pontiac MI | Hope Cancer Center, Pontiac MI | Saint Joseph Mercy Oakland, Pontiac MI | 21st Century Oncology-Pontiac, Pontiac MI | Oncology Hematology Associates of Saginaw Valley PC, Saginaw MI | Ascension Saint Mary’s Hospital, Saginaw MI | Bhadresh Nayak MD PC-Sterling Heights, Sterling Heights MI | Ascension Saint Joseph Hospital, Tawas City MI | Macomb Hematology Oncology PC, Warren MI | Saint John Macomb-Oakland Hospital, Warren MI | Michigan Breast Specialists-Warren, Warren MI | Advanced Breast Care Center PLLC, Warren MI | Great Lakes Cancer Management Specialists-Macomb Professional Building, Warren MI | Saint Mary’s Oncology / Hematology Associates of West Branch, West Branch MI | Huron Gastroenterology PC, Ypsilanti MI | IHA Hematology Oncology Consultants-Ann Arbor, Ypsilanti MI | Sanford Joe Lueken Cancer Center, Bemidji MN | Fairview Ridges Hospital, Burnsville MN | Minnesota Oncology – Burnsville, Burnsville MN | Cambridge Medical Center, Cambridge MN | Mercy Hospital, Coon Rapids MN | Fairview Southdale Hospital, Edina MN | Unity Hospital, Fridley MN | Fairview Clinics and Surgery Center Maple Grove, Maple Grove MN | Minnesota Oncology Hematology PA-Maplewood, Maplewood MN | Saint John’s Hospital – Healtheast, Maplewood MN | Abbott-Northwestern Hospital, Minneapolis MN | Health Partners Inc, Minneapolis MN | Hennepin County Medical Center, Minneapolis MN | Monticello Cancer Center, Monticello MN | New Ulm Medical Center, New Ulm MN | Fairview Northland Medical Center, Princeton MN | North Memorial Medical Health Center, Robbinsdale MN | Park Nicollet Clinic – Saint Louis Park, Saint Louis Park MN | United Hospital, Saint Paul MN | Regions Hospital, Saint Paul MN | Saint Francis Regional Medical Center, Shakopee MN | Lakeview Hospital, Stillwater MN | Sanford Thief River Falls Medical Center, Thief River Falls MN | Ridgeview Medical Center, Waconia MN | Rice Memorial Hospital, Willmar MN | Minnesota Oncology Hematology PA-Woodbury, Woodbury MN | Sanford Cancer Center Worthington, Worthington MN | Fairview Lakes Medical Center, Wyoming MN | Saint Louis Cancer and Breast Institute-Ballwin, Ballwin MO | Saint Francis Medical Center, Cape Girardeau MO | Southeast Cancer Center, Cape Girardeau MO | Parkland Health Center – Farmington, Farmington MO | Capital Region Southwest Campus, Jefferson City MO | Freeman Health System, Joplin MO | Mercy Hospital Joplin, Joplin MO | Delbert Day Cancer Institute at PCRMC, Rolla MO | Mercy Clinic-Rolla-Cancer and Hematology, Rolla MO | Heartland Regional Medical Center, Saint Joseph MO | Mercy Hospital South, Saint Louis MO | Mercy Hospital Saint Louis, Saint Louis MO | Saint Louis Cancer and Breast Institute-South City, Saint Louis MO | Missouri Baptist Medical Center, Saint Louis MO | Sainte Genevieve County Memorial Hospital, Sainte Genevieve MO | Mercy Hospital Springfield, Springfield MO | CoxHealth South Hospital, Springfield MO | Missouri Baptist Sullivan Hospital, Sullivan MO | Missouri Baptist Outpatient Center-Sunset Hills, Sunset Hills MO | Mercy Hospital Washington, Washington MO | University of Mississippi Medical Center, Jackson MS | Community Hospital of Anaconda, Anaconda MT | Billings Clinic Cancer Center, Billings MT | Bozeman Deaconess Hospital, Bozeman MT | Benefis Healthcare- Sletten Cancer Institute, Great Falls MT | Great Falls Clinic, Great Falls MT | Kalispell Regional Medical Center, Kalispell MT | Community Medical Hospital, Missoula MT | Saint Patrick Hospital – Community Hospital, Missoula MT | Sanford Bismarck Medical Center, Bismarck ND | Southpointe-Sanford Medical Center Fargo, Fargo ND | Sanford Roger Maris Cancer Center, Fargo ND | Sanford South University Medical Center, Fargo ND | Sanford Broadway Medical Center, Fargo ND | Sanford Medical Center Fargo, Fargo ND | CHI Health Saint Francis, Grand Island NE | CHI Health Good Samaritan, Kearney NE | Saint Elizabeth Regional Medical Center, Lincoln NE | Nebraska Methodist Hospital, Omaha NE | Alegent Health Bergan Mercy Medical Center, Omaha NE | Alegent Health Lakeside Hospital, Omaha NE | Creighton University Medical Center, Omaha NE | Alegent Health Immanuel Medical Center, Omaha NE | Midlands Community Hospital, Papillion NE | New Hampshire Oncology Hematology PA-Concord, Concord NH | Solinsky Center for Cancer Care, Manchester NH | Englewood Hospital and Medical Center, Englewood NJ | Carson Tahoe Regional Medical Center, Carson City NV | Urology Specialists of Nevada – Green Valley, Henderson NV | Comprehensive Cancer Centers of Nevada-Horizon Ridge, Henderson NV | Las Vegas Urology – Pebble, Henderson NV | OptumCare Cancer Care at Seven Hills, Henderson NV | 21st Century Oncology-Henderson, Henderson NV | Las Vegas Cancer Center-Henderson, Henderson NV | Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson NV | Cancer and Blood Specialists-Henderson, Henderson NV | Comprehensive Cancer Centers of Nevada – Henderson, Henderson NV | Las Vegas Urology – Green Valley, Henderson NV | Summerlin Hospital Medical Center, Las Vegas NV | Urology Specialists of Nevada – Central, Las Vegas NV | Las Vegas Urology – Cathedral Rock, Las Vegas NV | Urology Specialists of Nevada – Southwest, Las Vegas NV | Comprehensive Cancer Centers of Nevada – Central Valley, Las Vegas NV | Comprehensive Cancer Centers of Nevada – Town Center, Las Vegas NV | OptumCare Cancer Care at MountainView, Las Vegas NV | Desert West Surgery, Las Vegas NV | Comprehensive Cancer Centers of Nevada – Northwest, Las Vegas NV | Las Vegas Urology – Pecos, Las Vegas NV | University Cancer Center, Las Vegas NV | OptumCare Cancer Care at Fort Apache, Las Vegas NV | Las Vegas Prostate Cancer Center, Las Vegas NV | 21st Century Oncology-Fort Apache, Las Vegas NV | Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas NV | Urology Specialists of Nevada – Northwest, Las Vegas NV | OptumCare Cancer Care at Oakey, Las Vegas NV | Las Vegas Urology – Sunset, Las Vegas NV | Radiation Oncology Centers of Nevada Southeast, Las Vegas NV | Hope Cancer Care of Nevada, Las Vegas NV | Las Vegas Urology – Smoke Ranch, Las Vegas NV | 21st Century Oncology-Vegas Tenaya, Las Vegas NV | Radiation Oncology Centers of Nevada Central, Las Vegas NV | 21st Century Oncology, Las Vegas NV | Las Vegas Cancer Center-Medical Center, Las Vegas NV | University Medical Center of Southern Nevada, Las Vegas NV | Alliance for Childhood Diseases / Cure 4 the Kids Foundation, Las Vegas NV | Sunrise Hospital and Medical Center, Las Vegas NV | Comprehensive Cancer Centers of Nevada, Las Vegas NV | Hope Cancer Care of Nevada-Pahrump, Pahrump NV | Renown Regional Medical Center, Reno NV | Radiation Oncology Associates, Reno NV | Saint Mary’s Regional Medical Center, Reno NV | Hematology Oncology Associates of Central New York-Auburn, Auburn NY | Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse NY | Glens Falls Hospital, Glens Falls NY | Pluta Cancer Center, Rochester NY | University of Rochester, Rochester NY | Hematology Oncology Associates of Central New York-Onondaga Hill, Syracuse NY | Aultman Alliance Community Hospital, Alliance OH | Strecker Cancer Center-Belpre, Belpre OH | Aultman Health Foundation, Canton OH | Adena Regional Medical Center, Chillicothe OH | TriHealth Cancer Institute-Westside, Cincinnati OH | Bethesda North Hospital, Cincinnati OH | Good Samaritan Hospital – Cincinnati, Cincinnati OH | TriHealth Cancer Institute-Anderson, Cincinnati OH | Grant Medical Center, Columbus OH | Mount Carmel Health Center West, Columbus OH | Doctors Hospital, Columbus OH | Riverside Methodist Hospital, Columbus OH | Columbus Oncology and Hematology Associates Inc, Columbus OH | The Mark H Zangmeister Center, Columbus OH | Mount Carmel East Hospital, Columbus OH | Grady Memorial Hospital, Delaware OH | Delaware Health Center-Grady Cancer Center, Delaware OH | Dublin Methodist Hospital, Dublin OH | Central Ohio Breast and Endocrine Surgery, Gahanna OH | Mount Carmel Grove City Hospital, Grove City OH | Fairfield Medical Center, Lancaster OH | OhioHealth Mansfield Hospital, Mansfield OH | Marietta Memorial Hospital, Marietta OH | OhioHealth Marion General Hospital, Marion OH | Knox Community Hospital, Mount Vernon OH | Newark Radiation Oncology, Newark OH | Licking Memorial Hospital, Newark OH | Southern Ohio Medical Center, Portsmouth OH | Toledo Clinic Cancer Centers-Toledo, Toledo OH | Mercy Health – Saint Anne Hospital, Toledo OH | Saint Ann’s Hospital, Westerville OH | Genesis Healthcare System Cancer Care Center, Zanesville OH | Integris Cancer Institute of Oklahoma, Oklahoma City OK | University of Oklahoma Health Sciences Center, Oklahoma City OK | Integris Southwest Medical Center, Oklahoma City OK | Mercy Hospital Oklahoma City, Oklahoma City OK | Saint Alphonsus Medical Center-Baker City, Baker City OR | Saint Charles Health System, Bend OR | Providence Cancer Institute Clackamas Clinic, Clackamas OR | Clackamas Radiation Oncology Center, Clackamas OR | Bay Area Hospital, Coos Bay OR | Legacy Mount Hood Medical Center, Gresham OR | Providence Newberg Medical Center, Newberg OR | Saint Alphonsus Medical Center-Ontario, Ontario OR | Legacy Good Samaritan Hospital and Medical Center, Portland OR | Providence Saint Vincent Medical Center, Portland OR | Providence Portland Medical Center, Portland OR | Saint Charles Health System-Redmond, Redmond OR | Legacy Meridian Park Hospital, Tualatin OR | Lehigh Valley Hospital-Cedar Crest, Allentown PA | Lehigh Valley Hospital – Muhlenberg, Bethlehem PA | Chambersburg Hospital, Chambersburg PA | Pocono Medical Center, East Stroudsburg PA | Ephrata Community Hospital, Ephrata PA | Ephrata Cancer Center, Ephrata PA | Adams Cancer Center, Gettysburg PA | Cherry Tree Cancer Center, Hanover PA | Lehigh Valley Hospital-Hazleton, Hazleton PA | Sechler Family Cancer Center, Lebanon PA | Pottstown Hospital, Pottstown PA | Reading Hospital, West Reading PA | WellSpan Health-York Cancer Center, York PA | WellSpan Health-York Hospital, York PA | Women and Infants Hospital, Providence RI | Saint Francis Hospital, Greenville SC | Saint Francis Cancer Center, Greenville SC | Lexington Medical Center, West Columbia SC | Sanford USD Medical Center – Sioux Falls, Sioux Falls SD | Sanford Cancer Center Oncology Clinic, Sioux Falls SD | Saint Joseph Regional Cancer Center, Bryan TX | Parkland Memorial Hospital, Dallas TX | UT Southwestern / Simmons Cancer Center-Dallas, Dallas TX | UT Southwestern / Simmons Cancer Center-Fort Worth, Fort Worth TX | Ben Taub General Hospital, Houston TX | Houston Methodist Hospital, Houston TX | Baylor College of Medicine / Dan L Duncan Comprehensive Cancer Center, Houston TX | Doctor’s Hospital of Laredo, Laredo TX | Kaiser Permanente-Burke Medical Center, Burke VA | Inova Schar Cancer Institute, Fairfax VA | Inova Fair Oaks Hospital, Fairfax VA | Kaiser Permanente Tysons Corner Medical Center, McLean VA | Bon Secours Memorial Regional Medical Center, Mechanicsville VA | Bon Secours Saint Francis Medical Center, Midlothian VA | Bon Secours DePaul Medical Center, Norfolk VA | Bon Secours Maryview Medical Center, Portsmouth VA | Bon Secours Saint Mary’s Hospital, Richmond VA | Bon Secours Cancer Institute at Reynolds Crossing, Richmond VA | Bon Secours Health Center at Harbour View, Suffolk VA | Providence Regional Cancer System-Aberdeen, Aberdeen WA | Overlake Medical Center, Bellevue WA | PeaceHealth Saint Joseph Medical Center, Bellingham WA | Harrison HealthPartners Hematology and Oncology-Bremerton, Bremerton WA | Harrison Medical Center, Bremerton WA | Highline Medical Center-Main Campus, Burien WA | Providence Regional Cancer System-Centralia, Centralia WA | Swedish Cancer Institute-Edmonds, Edmonds WA | Saint Elizabeth Hospital, Enumclaw WA | Providence Regional Cancer Partnership, Everett WA | Saint Francis Hospital, Federal Way WA | Swedish Cancer Institute-Issaquah, Issaquah WA | Kadlec Clinic Hematology and Oncology, Kennewick WA | Providence Regional Cancer System-Lacey, Lacey WA | Saint Clare Hospital, Lakewood WA | PeaceHealth Saint John Medical Center, Longview WA | Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo WA | Valley Medical Center, Renton WA | Swedish Medical Center-First Hill, Seattle WA | Swedish Medical Center-Ballard Campus, Seattle WA | Swedish Medical Center-Cherry Hill, Seattle WA | Pacific Gynecology Specialists, Seattle WA | PeaceHealth United General Medical Center, Sedro-Woolley WA | Providence Regional Cancer System-Shelton, Shelton WA | Franciscan Research Center-Northwest Medical Plaza, Tacoma WA | Northwest Medical Specialties PLLC, Tacoma WA | Legacy Salmon Creek Hospital, Vancouver WA | Legacy Cancer Institute Medical Oncology and Day Treatment, Vancouver WA | PeaceHealth Southwest Medical Center, Vancouver WA | Providence Saint Mary Regional Cancer Center, Walla Walla WA | Providence Regional Cancer System-Yelm, Yelm WA | ProHealth D N Greenwald Center, Mukwonago WI | Cancer Center of Western Wisconsin, New Richmond WI | ProHealth Oconomowoc Memorial Hospital, Oconomowoc WI | ProHealth Waukesha Memorial Hospital, Waukesha WI | UW Cancer Center at ProHealth Care, Waukesha WI | Billings Clinic-Cody, Cody WY | Welch Cancer Center, Sheridan WY |

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Last status change to Active was on 2021-01-06.

For the complete listing see here: NCI-2020-03770

Preoperative Use of Radiation to Enhance the Effectiveness of Immune Checkpoint Blockade Therapy in Operable Breast Cancer

Preoperative Use of Radiation Boost to Enhance Effectiveness of Immune Checkpoint Blockade Therapy in Operable Breast Cancer

Phase I_II

This phase Ib / II trial studies the effect of hypofractionated radiation therapy and pembrolizumab when given before surgery (preoperative) in treating breast cancer that can be treated by surgery (operable). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more cancer cells and have fewer side effects. Giving pembrolizumab with or without radiation therapy before standard of care surgery may work better in treating breast cancer.

This trial may be offered at the following sites in the US (please check with center directly):

University of Pennsylvania / Abramson Cancer Center, Philadelphia PA |

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Last status change to Active was on 2021-01-06.

For the complete listing see here: NCI-2021-00217

Testing the Addition of Copanlisib to Usual Treatment (Fulvestrant and Abemaciclib) in Metastatic Breast Cancer

A Randomized Phase I / II Trial of Fulvestrant and Abemaciclib in Combination with Copanlisib (FAC) versus Fulvestrant and Abemaciclib Alone (FA) for Endocrine-Resistant, Hormone Receptor Positive, HER2 Negative Metastatic Breast Cancer (FAC vs FA)

Phase I_II

This phase I / II trial studies the effects (good and bad) of adding copanlisib to the usual therapy of fulvestrant and abemaciclib in treating patients with hormone receptor positive and HER2 negative stage IV breast cancer. Some breast cancer cells have receptors for the hormones estrogen or progesterone. These cells are hormone receptor positive and they need estrogen or progesterone to grow. This can affect how the cancer is treated. Hormone therapy using fulvestrant may fight breast cancer by blocking the use of estrogen by the tumor cells. Abemaciclib and copanlisib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Adding copanlisib to the usual therapy of fulvestrant and abemaciclib may work better than giving fulvestrant and abemaciclib alone in treating patients with breast cancer.

This trial may be offered at the following sites in the US (please check with center directly):

University of Alabama at Birmingham Cancer Center, Birmingham AL | UC Irvine Health / Chao Family Comprehensive Cancer Center, Orange CA | University of Kentucky / Markey Cancer Center, Lexington KY | Siteman Cancer Center at West County Hospital, Creve Coeur MO | Siteman Cancer Center-South County, Saint Louis MO | Washington University School of Medicine, Saint Louis MO | Siteman Cancer Center at Christian Hospital, Saint Louis MO | Siteman Cancer Center at Saint Peters Hospital, Saint Peters MO | Bellevue Hospital Center, New York NY | Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York NY | Ohio State University Comprehensive Cancer Center, Columbus OH |

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Last status change to Active was on 2020-12-30.

For the complete listing see here: NCI-2019-02752

Study to Evaluate the Safety and Antitumor Activity of CX-2009 Monotherapy and in Combination With CX-072 in Advanced Breast Cancer

A Phase 2, Open-Label Study to Evaluate the Safety and Antitumor Activity of CX-2009 in Advanced HR-Positive / HER2-Negative Breast Cancer and of CX-2009 as Monotherapy and in Combination With CX-072 in Advanced Triple-Negative Breast Cancer

Phase II

A Phase 2, clinical study in advanced, metastatic breast cancer that will evaluate CX-2009 monotherapy in both Hormone Receptor(HR) positive / HER2 negative breast cancer and in TNBC, and evaluate CX-2009+CX-072 in TNBC

This trial may be offered at the following sites in the US (please check with center directly):

UCLA / Jonsson Comprehensive Cancer Center, Los Angeles CA | IU Health North Hospital, Carmel IN | Indiana University / Melvin and Bren Simon Cancer Center, Indianapolis IN | Sidney and Lois Eskenazi Hospital, Indianapolis IN |

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Last status change to Active was on 2020-12-29.

For the complete listing see here: NCI-2021-00010

Hormonal Therapy after Pertuzumab and Trastuzumab for the Treatment of Hormone Receptor Positive, HER2 Positive Breast Cancer, the ADEPT study

A Single Arm Phase II Study of Adjuvant Endocrine Therapy, Subcutaneous Pertuzumab, and Trastuzumab Fixed-Dose Combination for Patients with Anatomic Stage I Hormone Receptor-Positive, HER2-Positive Breast Cancer (ADEPT)

Phase II

This phase II trial studies the effect of hormonal therapy given after (adjuvant) pertuzumab and trastuzumab in treating patients with hormone receptor positive, HER2 positive breast cancer. The drugs trastuzumab and pertuzumab are both monoclonal antibodies, which are disease-fighting proteins made by cloned immune cells. Estrogen can cause the growth of breast cancer cells. Hormonal therapy, such as letrozole, anastrozole, exemestane, and tamoxifen, block the use of estrogen by the tumor cells. Giving hormonal therapy after pertuzumab and trastuzumab may kill any remaining tumor cells in patients with breast cancer.

This trial may be offered at the following sites in the US (please check with center directly):

Dana-Farber Cancer Institute, Boston MA |

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Last status change to Active was on 2020-12-21.

For the complete listing see here: NCI-2020-13971

Niraparib and Dostarlimab as Neoadjuvant Treatment for Patients with BRCA-Mutated Stage I-III Breast Cancer

A Phase II Study of Niraparib with Dostarlimab Therapy as Neoadjuvant Treatment for Patients with BRCA-Mutated Breast Cancer

Phase II

This phase II trial studies the effects of niraparib in combination with dostarlimab prior to surgery in treating BRCA-mutated stage I-III breast cancer. Niraparib is a PARP inhibitor, which means that it blocks an enzyme (proteins that help chemical reactions in the body occur) in cells called PARP. PARP helps repair deoxyribonucleic acid (DNA) when it becomes damaged. Blocking PARP may help keep cancer cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy. Dostarlimab stimulates the immune system by blocking the PD-1 pathway. The PD-1 pathway controls the body’s natural immune response, but for some types of cancer, the immune system does not work as it should and is prevented from attacking tumors. Dostarlimab works by blocking the PD-1 pathway, which may help your immune system identify and catch tumor cells. Giving niraparib in combination with dostarlimab may work better against the tumor and maximize tumor shrinkage before surgery.

This trial may be offered at the following sites in the US (please check with center directly):

Dana-Farber Cancer Institute, Boston MA | Brigham and Women’s Hospital, Boston MA |

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Last status change to Active was on 2020-12-18.

For the complete listing see here: NCI-2020-13969

Testing Sacituzumab Govitecan Therapy in Patients with HER2-Negative Breast Cancer and Brain Metastases

A Phase II Trial of Sacituzumab Govitecan (IMMU-132) (NSC #820016) for Patients with HER2-Negative Breast Cancer and Brain Metastases

Phase II

This phase II trial studies the effect of sacituzumab govitecan in treating patients with HER2-negative breast cancer that has spread to the brain (brain metastases). Sacituzumab govitecan is a monoclonal antibody, called sacituzumab, linked to a chemotherapy drug, called govitecan. Sacituzumab is a form of targeted therapy because it attaches to specific molecules on the surface of cancer cells, known as Trop-2 receptors, and delivers govitecan to kill them. Giving sacituzumab govitecan may shrink the cancer in the brain and / or extend the time until the cancer gets worse.

This trial may be offered at the following sites in the US (please check with center directly):

Mercy Hospital Fort Smith, Ft. Smith AR | McFarland Clinic PC – Ames, Ames IA | Mary Greeley Medical Center, Ames IA | McFarland Clinic PC-Boone, Boone IA | McFarland Clinic PC-Trinity Cancer Center, Fort Dodge IA | McFarland Clinic PC-Jefferson, Jefferson IA | McFarland Clinic PC-Marshalltown, Marshalltown IA | Saint Alphonsus Cancer Care Center-Boise, Boise ID | Saint Alphonsus Cancer Care Center-Caldwell, Caldwell ID | Kootenai Medical Center, Coeur D’Alene ID | Walter Knox Memorial Hospital, Emmett ID | Idaho Urologic Institute-Meridian, Meridian ID | Saint Alphonsus Medical Center-Nampa, Nampa ID | Kootenai Cancer Center, Post Falls ID | Kootenai Cancer Clinic, Sandpoint ID | Illinois CancerCare-Bloomington, Bloomington IL | Illinois CancerCare-Canton, Canton IL | Memorial Hospital of Carbondale, Carbondale IL | SIH Cancer Institute, Carterville IL | Illinois CancerCare-Carthage, Carthage IL | Centralia Oncology Clinic, Centralia IL | Decatur Memorial Hospital, Decatur IL | Cancer Care Specialists of Illinois – Decatur, Decatur IL | Illinois CancerCare-Dixon, Dixon IL | Crossroads Cancer Center, Effingham IL | Illinois CancerCare-Eureka, Eureka IL | Western Illinois Cancer Treatment Center, Galesburg IL | Illinois CancerCare-Galesburg, Galesburg IL | Illinois CancerCare-Kewanee Clinic, Kewanee IL | Illinois CancerCare-Macomb, Macomb IL | Good Samaritan Regional Health Center, Mount Vernon IL | Cancer Care Center of O’Fallon, O’Fallon IL | Illinois CancerCare-Ottawa Clinic, Ottawa IL | Illinois CancerCare-Pekin, Pekin IL | Illinois CancerCare-Peoria, Peoria IL | Methodist Medical Center of Illinois, Peoria IL | Valley Radiation Oncology, Peru IL | Illinois CancerCare-Peru, Peru IL | Illinois CancerCare-Princeton, Princeton IL | Springfield Clinic, Springfield IL | Memorial Medical Center, Springfield IL | Southern Illinois University School of Medicine, Springfield IL | Walter Reed National Military Medical Center, Bethesda MD | Hickman Cancer Center, Adrian MI | Toledo Clinic Cancer Centers-Monroe, Monroe MI | Saint Louis Cancer and Breast Institute-Ballwin, Ballwin MO | Southeast Cancer Center, Cape Girardeau MO | Saint Francis Medical Center, Cape Girardeau MO | Parkland Health Center – Farmington, Farmington MO | Capital Region Southwest Campus, Jefferson City MO | Freeman Health System, Joplin MO | Mercy Hospital Joplin, Joplin MO | Mercy Clinic-Rolla-Cancer and Hematology, Rolla MO | Delbert Day Cancer Institute at PCRMC, Rolla MO | Heartland Regional Medical Center, Saint Joseph MO | Mercy Hospital Saint Louis, Saint Louis MO | Missouri Baptist Medical Center, Saint Louis MO | Mercy Hospital South, Saint Louis MO | Saint Louis Cancer and Breast Institute-South City, Saint Louis MO | Sainte Genevieve County Memorial Hospital, Sainte Genevieve MO | Mercy Hospital Springfield, Springfield MO | CoxHealth South Hospital, Springfield MO | Missouri Baptist Sullivan Hospital, Sullivan MO | Missouri Baptist Outpatient Center-Sunset Hills, Sunset Hills MO | Mercy Hospital Washington, Washington MO | Community Hospital of Anaconda, Anaconda MT | Billings Clinic Cancer Center, Billings MT | Bozeman Deaconess Hospital, Bozeman MT | Benefis Healthcare- Sletten Cancer Institute, Great Falls MT | Great Falls Clinic, Great Falls MT | Kalispell Regional Medical Center, Kalispell MT | Community Medical Hospital, Missoula MT | Southeastern Medical Oncology Center-Clinton, Clinton NC | Southeastern Medical Oncology Center-Goldsboro, Goldsboro NC | Southeastern Medical Oncology Center-Jacksonville, Jacksonville NC | Mercy Health – Saint Anne Hospital, Toledo OH | Toledo Clinic Cancer Centers-Toledo, Toledo OH | Mercy Hospital Oklahoma City, Oklahoma City OK | Saint Alphonsus Medical Center-Baker City, Baker City OR | Saint Alphonsus Medical Center-Ontario, Ontario OR | UPMC Pinnacle Cancer Center / Community Osteopathic Campus, Harrisburg PA | University of Pittsburgh Cancer Institute (UPCI), Pittsburgh PA | UPMC-Mercy Hospital, Pittsburgh PA | UPMC Susquehanna, Williamsport PA | UPMC Memorial, York PA | Billings Clinic-Cody, Cody WY | Welch Cancer Center, Sheridan WY |

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Last status change to Active was on 2020-12-15.

For the complete listing see here: NCI-2020-07706

Preoperative Chemotherapy, Pembrolizumab, and No, Low, or High Dose Radiation for the Treatment of Node-Positive, HER2-Negative Breast Cancer, P-RAD

P-RAD: A Randomized Study of Preoperative Chemotherapy, Pembrolizumab and No, Low or High Dose Radiation in Node-Positive, HER2-Negative Breast Cancer

Phase II

This phase II trial studies the effect of chemotherapy and pembrolizumab with or without radiation therapy before surgery in treating patients with node-positive, HER2 negative breast cancer. Chemotherapy drugs, such as paclitaxel, doxorubicin, and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Radiation therapy uses high energy protons to kill tumor cells and shrink tumors. Giving chemotherapy and pembrolizumab with radiation therapy may kill more cancer cells.

This trial may be offered at the following sites in the US (please check with center directly):

Massachusetts General Hospital Cancer Center, Boston MA |

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Last status change to Active was on 2020-12-02.

For the complete listing see here: NCI-2020-13347

BN-Brachyury, Entinostat, Adotrastuzumab Emtansine and M7824 in Advanced Stage Breast Cancer (BrEAsT)

A Phase 1b Trial of Sequential Combinations of BN-Brachyury, Entinostat, Ado-trastuzuamb Emtansine and M7824 in Advanced Stage Breast Cancer (BrEAsT)

Phase I

Background: Breast cancer is the second most common cause of U.S. cancer deaths in women. Immunotherapy drugs use a person s immune system to fight cancer. Researchers want to see if a new combination of immunotherapy drugs can help treat breast cancer that has gone to places in the body outside of the breast (metastasized). Objective: To learn if a new combination of immunotherapy drugs can shrink tumors in people with metastatic breast cancer. Eligibility: Adults 18 and older who have been diagnosed with metastatic breast cancer, such as Triple Negative Breast Cancer (TNBC) or ER- / PR- / HER2+ Breast Cancer (HER2+BC) Design: Participants will be screened with: medical history physical exam disease confirmation (or tumor biopsy) tumor scans (computed tomography, magnetic resonance imaging, and / or bone scan) blood and urine tests electrocardiogram (measures the heart s electrical activity) echocardiogram (creates images of the heart). Participants will be assigned to 1 of 3 groups. The drugs they get will be based on the group they are in. Drugs are given in cycles. Each cycle = 3 weeks. Participants will be seen in clinic every 3 weeks, prior to the start of a new cycle. At each visit, participants will have an clinical exam, have blood drawn and will be asked about any side effects. They will repeat the screening tests during the study. New scans, like a CT scan, will be done every 6 weeks to see if the treatment is working. All participants will get BN-Brachyury. It is 2 different vaccines – a prime and a boost. First the priming vaccines, called MVA-BN-Brachyury help to jump start the immune system. Next the boosting vaccines, called FPV-Brachyury help to keep the immune system going. They are injected under the skin during different cycles. All participants will get M7824 (also known as Bintrafusp alfa ), which is an immunotherapy drug. Some participants will get a commonly used drug is HER2+ breast cancer called adotrastuzumab emtansine (also known as T-DM1DM1 or kadcyla). For both, a needle is inserted into a vein to give the drugs slowly. Some participants will take Entinostat weekly by mouth. It is in tablet form. Participants will keep a pill diary. Participants will continue on their assigned treatment until their cancer grows, they develop side effects or want to stop treatment. About 28 days after treatment ends, participants will have a follow-up visit or a telephone call. Then they will be contacted every 3 months for 1 year, then every 6 months for 1 year. They may have more tumor scans or continue treatment.

This trial may be offered at the following sites in the US (please check with center directly):

National Institutes of Health Clinical Center, Bethesda MD | Ohio State University Comprehensive Cancer Center, Columbus OH |

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Last status change to Active was on 2020-11-25.

For the complete listing see here: NCI-2020-01659

Study of a Shortened Radiation Therapy Schedule in Patients with Breast Cancer, the FAST-R Trial

Fractionation Accelerated beyond Standard Therapy for Post-Mastectomy Radiotherapy in Patients with Reconstructions (FAST-R Trial): A Prospective Non-Inferiority Trial of Ultra-Compressed Treatment

Phase O

This early phase I trial is to find out the side effects and possible benefits of providing radiation on a shortened (compressed) schedule of 5 days in a row in preventing cancer from coming back in patients with invasive stage IIA-IIIA breast cancer who have undergone surgery to remove the breast or as much of the breast tissue as possible. (mastectomy). A standard schedule of radiation after mastectomy is 16-25 days. Undergoing a compressed schedule may decrease the amount of time patients must spend in the clinic for radiation treatments and reduce the disruption in patients’ routine activities (such as employment or childcare) that can occur with a long course of treatment. This trial may help the researchers learn whether the compressed 5-day schedule is better than, the same as, or worse than the standard 16-25 day schedule.

This trial may be offered at the following sites in the US (please check with center directly):

Memorial Sloan Kettering Basking Ridge, Basking Ridge NJ | Memorial Sloan Kettering Bergen, Montvale NJ | Memorial Sloan Kettering Commack, Commack NY | Memorial Sloan Kettering Cancer Center, New York NY | Memorial Sloan Kettering Nassau, Uniondale NY | Memorial Sloan Kettering Westchester, West Harrison NY |

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Last status change to Active was on 2020-11-24.

For the complete listing see here: NCI-2020-13136

Chemotherapy and Nivolumab Alone or in Combination with Cabiralizumab for the Treatment of Stage II-III Triple-Negative Breast Cancer

Phase Ib / II Study to Evaluate Safety and Tolerability of Cabiralizumab in Combination with Nivolumab and Neoadjuvant Chemotherapy in Patients with Localized Triple-Negative Breast Cancer

Phase I_II

This phase Ib / II trial studies the side effects of chemotherapy and nivolumab alone or in combination with cabiralizumab and to see how well they work in treating patients with stage II-III triple-negative breast cancer. Chemotherapy drugs, like paclitaxel and carboplatin, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Cabiralizumab may interfere with the ability of cancer cells to grow and spread. Adding cabiralizumab to chemotherapy and nivolumab may improve how a patient’s immune system becomes stimulated to fight cancer.

This trial may be offered at the following sites in the US (please check with center directly):

Siteman Cancer Center at Washington University, Saint Louis MO |

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Last status change to Active was on 2020-11-19.

For the complete listing see here: NCI-2020-06347

Radiation Therapy Followed by Trastuzumab and Pertuzumab for the Treatment of HER2 Positive Breast Cancer that has Spread to the Leptomeninges

Phase I / II Study of Radiation Therapy Followed by Intrathecal Trastuzumab / Pertuzumab in the Management of HER2+ Breast Leptomeningeal Disease

Phase I_II

This phase I / II trial studies the side effects and best dose of pertuzumab when given together with trastuzumab after radiation therapy and to see how well it works in treating patients with HER2 positive breast cancer that has spread to the leptomeninges. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Pertuzumab and trastuzumab are called targeted therapies because they work by attaching themselves to specific receptors on the surface of breast tumor cells, known as HER2 receptors. HER2 receptors can be found on normal cells, but can also be found in larger numbers on some tumor cells. When these targeted therapies attach to HER2 receptors, cell growth signals within the cell are blocked and the tumor cell may be marked for destruction by the immune system. This process allows pertuzumab and trastuzumab to help slow or stop the growth of breast cancer. Pertuzumab and trastuzumab target different areas on the HER2 receptor, so they are believed to work together more effectively when combined after radiation therapy. Giving pertuzumab and trastuzumab after radiation therapy may help treat patients with HER2 positive breast cancer that has spread to the leptomeninges.

This trial may be offered at the following sites in the US (please check with center directly):

Moffitt Cancer Center, Tampa FL |

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Last status change to Active was on 2020-11-18.

For the complete listing see here: NCI-2020-11618

Pembrolizumab and Binimetinib in Treating Patients with Locally Advanced or Metastatic Triple Negative Breast Cancer

Phase I / II Trial of Pembrolizumab in Combination with Binimetinib in Unresectable Locally Advanced or Metastatic Triple Negative Breast Cancer

Phase I_II

This phase I / II trial studies the best dose of pembrolizumab and binimetinib and how well it works when given together with pembrolizumab in treating patients with triple negative breast cancer that has spread to other parts of the body (metastatic). Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Binimetinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving pembrolizumab and binimetinib may work better in treating patients with triple negative breast cancer.

This trial may be offered at the following sites in the US (please check with center directly):

Mayo Clinic in Florida, Jacksonville FL | Mayo Clinic in Rochester, Rochester MN |

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Last status change to Active was on 2020-11-10.

For the complete listing see here: NCI-2017-00496

Tavo and Pembrolizumab With or Without Chemotherapy in Patients With Inoperable Locally Advanced or Metastatic TNBC

A Phase 2, Multi-Cohort, Open-Label Study of Intratumoral Tavokinogene Telseplasmid Plus Electroporation in Combination With Intravenous Pembrolizumab Therapy With or Without Chemotherapy in Patients With Inoperable Locally Advanced or Metastatic Triple Negative Breast Cancer (TNBC)

Phase II

This is a Phase 2, Multi-Cohort, Open-Label, Multi-Center Study. Cohort 1 will be a single-arm study of intratumoral tavokinogene telseplasmid (tavo) plus electroporation (EP) in combination with pembrolizumab therapy. Cohort 2 will be a single-arm study of intratumoral tavo-EP plus pembrolizumab with nab-paclitaxel (Abraxane®) chemotherapy. Subjects with TNBC and EP accessible cutaneous / subcutaneous disease will be enrolled in this study.

This trial may be offered at the following sites in the US (please check with center directly):

Stanford Cancer Institute Palo Alto, Palo Alto CA | Moffitt Cancer Center, Tampa FL | Fred Hutch / University of Washington Cancer Consortium, Seattle WA |

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Last status change to Active was on 2020-10-23.

For the complete listing see here: NCI-2018-02482

Testing the Addition of an Individualized Vaccine to Nab-Paclitaxel, Durvalumab and Tremelimumab and Chemotherapy in Patients with Metastatic Triple Negative Breast Cancer

Randomized Phase 2 Clinical Trial of Nab-Paclitaxel + MEDI4736 (Durvalumab) + Tremelimumab + Neoantigen Vaccine vs. Nab-Paclitaxel + MEDI4736 (Durvalumab) + Tremelimumab in Patients with Metastatic Triple Negative Breast Cancer

Phase II

This phase II trial studies how well nab-paclitaxel, durvalumab, and tremelimumab with or without personalized synthetic long peptide vaccine (neoantigen vaccine) works in treating patients with triple negative breast cancer that has spread to other places in the body (metastatic). Drugs used in chemotherapy, such as nab-paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as durvalumab and tremelimumab, may induce changes in body’s immune system and may interfere with the ability of tumor cells to grow and spread. Vaccines made from peptides may help the body build an effective immune response to kill tumor cells. It is not yet known whether giving nab-paclitaxel, durvalumab, and tremelimumab with or without neoantigen vaccine will work better in treating patients with triple negative breast cancer.

This trial may be offered at the following sites in the US (please check with center directly):

UC Irvine Health / Chao Family Comprehensive Cancer Center, Orange CA | University of California Davis Comprehensive Cancer Center, Sacramento CA | University of Colorado Hospital, Aurora CO | Siteman Cancer Center at West County Hospital, Creve Coeur MO | Siteman Cancer Center-South County, Saint Louis MO | Siteman Cancer Center at Christian Hospital, Saint Louis MO | Washington University School of Medicine, Saint Louis MO | Siteman Cancer Center at Saint Peters Hospital, Saint Peters MO |

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Last status change to Active was on 2020-10-16.

For the complete listing see here: NCI-2018-01581

Olaparib, Palbociclib, and Fulvestrant in Treating Patients with BRCA Mutation-Associated, Hormone Receptor-Positive, and HER2-Negative Advanced Breast Cancer

A Phase I / II Trial of Olaparib, Palbociclib and Fulvestrant in Patients with BRCA Mutation-Associated, Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Metastatic Breast Cancer

Phase I_II

This phase I / II trial studies the best dose and side effects of palbociclib when given together with olaparib and fulvestrant, and to see how well they work in treating patients with BRCA mutation-associated, hormone receptor-positive, HER2-negative breast cancer that has spread from its original site of growth to nearby tissues or lymph nodes and cannot be removed by surgery, or has spread to other places in the body (advanced). Palbociclib and olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Anti-hormone therapy consisting of fulvestrant may prevent breast cancer cell growth by blocking estrogen and progesterone receptor stimulation. This trial studies the effectiveness of the combination of palbociclib, olaparib and fulvestrant.

This trial may be offered at the following sites in the US (please check with center directly):

Memorial Sloan Kettering Cancer Center, New York NY | University of Pennsylvania / Abramson Cancer Center, Philadelphia PA |

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Last status change to Active was on 2020-10-15.

For the complete listing see here: NCI-2019-04210

Infigratinib in Combination with Tamoxifen for the Treatment of Hormone Receptor-Positive, HER2-Negative Metastatic or Locally Recurrent Unresectable Breast Cancer

A Phase 1B Study of Infigratinib in Combination with Tamoxifen in Hormone Receptor-Positive, HER2-Negative, FGFR-Altered Advanced Breast Cancer

Phase I

This phase IB trial evaluates the best dose of infigratinib when given in combination with tamoxifen in treating patients with hormone receptor-positive, HER2-negative breast cancer that has spread to other places in the body (metastatic) or has come back (recurrent) and cannot be removed by surgery (unresectable). Infigratinib, a drug that targets the FGFR cancer pathway, may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Estrogen can cause the growth of breast cancer cells. Tamoxifen blocks the use of estrogen by tumor cells. Researchers hope to learn if infigratinib, a drug that targets the FGFR cancer pathway, can be safely added to current anti-hormonal therapies, specifically those including tamoxifen (Nolvadex or Soltamox).

This trial may be offered at the following sites in the US (please check with center directly):

Stanford Cancer Institute Palo Alto, Palo Alto CA |

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Last status change to Active was on 2020-10-13.

For the complete listing see here: NCI-2020-13784

Bintrafusp Alfa in High Mobility Group AT-Hook 2 (HMGA2) Expressing Triple Negative Breast Cancer

A Phase II, Multicenter, Open Label Study of Bintrafusp Alfa (M7824) Monotherapy in Participants With HMGA2-expressing Triple Negative Breast Cancer

Phase II

The main purpose of this study is to evaluate bintrafusp alfa monotherapy in participants with triple negative breast cancer (TNBC) who express high levels of HMGA2 as determined by a centralized reverse transcriptase-polymerase chain reaction (RT-PCR) test.

This trial may be offered at the following sites in the US (please check with center directly):

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh PA |

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Last status change to Active was on 2020-10-12.

For the complete listing see here: NCI-2021-01370

Trastuzumab Deruxtecan alone or in combination with Anastrozole for the Treatment of Early Stage HER2 Low, Hormone Receptor Positive Breast Cancer

A Phase II, Multicenter, Open-Label Trial to Evaluate the Safety and Efficacy of Trastuzumab Deruxtecan (DS-8201a) with or without Anastrozole for HER2 Low Hormone Receptor Positive (HR+) Breast Cancer in the Neoadjuvant Setting

Phase II

This phase II trial investigates how well trastuzumab deruxtecan works alone or in combination with anastrozole in treating patients with HER2 low, hormone receptor positive breast cancer. HER2 is protein involved in normal cell growth. It may be made in larger than normal amounts by some types of cancer cells which may cause cancer cells to grow more quickly. Hormone receptor positive describes cells that have a group of proteins that bind to a specific hormone such as estrogen or progesterone. These cancer cells need these hormones to grow. Trastuzumab deruxtecan is a monoclonal antibody, called trastuzumab, linked to a chemotherapy drug called deruxtecan. Trastuzumab attaches to HER2 cancer cells in a targeted way and delivers deruxtecan to kill them. Anastrozole works by decreasing estrogen production and suppressing the growth of tumors that need estrogen to grow. Trastuzumab deruxtecan alone or in combination with anastrozole may be effective in treating HER2 positive hormone receptor positive breast cancer.

This trial may be offered at the following sites in the US (please check with center directly):

UCLA / Jonsson Comprehensive Cancer Center, Los Angeles CA | Translational Research In Oncology – US Inc, Los Angeles CA |

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Last status change to Active was on 2020-10-09.

For the complete listing see here: NCI-2020-06086

Amcenestrant (SAR439859) Plus Palbociclib as First Line Therapy for Patients With ER (+) HER2(-) Advanced Breast Cancer

A Randomized, Multicenter, Double-blind Phase 3 Study of Amcenestrant (SAR439859) Plus Palbociclib Versus Letrozole Plus Palbociclib for the Treatment of Patients With ER (+), HER2 (-) Breast Cancer Who Have Not Received Prior Systemic Anti-cancer Treatment for Advanced Disease

Phase III

Primary Objective: To determine whether Amcenestrant (SAR439859) in combination with palbociclib improvesprogression free survival (PFS) when compared with letrozole in combination with palbociclib in participants with ER+, HER2- advanced breast cancer who have not received any prior systemic anticancer therapies for advanced disease. Secondary Objective: – To compare the overall survival in both treatment arms – To evaluate the objective response rate in both treatment arms – To evaluate the duration of response in both treatment arms – To evaluate the clinical benefit rate in both treatment arms – To evaluate progression-free survival on next line of therapy – To evaluate the pharmacokinetics of amcenestrant, and palbociclib – To evaluate health-related quality of life in both treatment arms – To evaluate the time to first chemotherapy in both treatment arms – To evaluate safety in both treatment arms

This trial may be offered at the following sites in the US (please check with center directly):

UCLA / Jonsson Comprehensive Cancer Center, Los Angeles CA | University of California San Francisco, San Francisco CA | University of Iowa / Holden Comprehensive Cancer Center, Iowa City IA | University of Kansas Cancer Center, Kansas City KS | Wake Forest University Health Sciences, Winston-Salem NC | Rutgers Cancer Institute of New Jersey, New Brunswick NJ | Virginia Commonwealth University / Massey Cancer Center, Richmond VA |

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Last status change to Active was on 2020-10-01.

For the complete listing see here: NCI-2020-07111

A Study of the Safety, Efficacy, and Pharmacokinetics of Tiragolumab in Combination With Atezolizumab and Chemotherapy in Participants With Triple-Negative Breast Cancer

A Phase Ib, Open-Label, Multicohort Study of the Safety, Efficacy, and Pharmacokinetics of Tiragolumab in Combination With Atezolizumab and Chemotherapy in Patients With Triple-Negative Breast Cancer

Phase I

The purpose of this study is to evaluate the safety, efficacy, and pharmacokinetics of tiragolumab in combination with atezolizumab and chemotherapy in participants with metastatic and early triple-negative breast cancer (TNBC).

This trial may be offered at the following sites in the US (please check with center directly):

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh PA |

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Last status change to Active was on 2020-09-28.

For the complete listing see here: NCI-2020-11524

Sacituzumab Govitecan Alone or in Combination with Pembrolizumab for the Treatment of Hormone Receptor+, HER2-, and PD-L1+ Metastatic Breast Cancer

Saci-IO HR+: Randomized Phase II Study of Sacituzumab Govitecan with or without Pembrolizumab in Hormone Receptor-Positive (HR+) / HER2- Metastatic Breast Cancer (MBC)

Phase II

This phase II trial studies the effect of sacituzumab govitecan alone or in combination with pembrolizumab in treating patients with hormone receptor positive (HR+) / HER2 negative, PD-L1 positive breast cancer that has spread to other places in the body (metastatic). Sacituzumab govitecan is composed of a chemotherapy drug, called irinotecan, which is attached to an antibody, which are proteins normally made by the immune system that bind to substances that don’t belong in the body to prevent harm. The antibody in this study binds to certain types of cancer tumors, including HR+ / HER2- tumors. Pembrolizumab is an immunotherapy, called an anti-PD-1 or a checkpoint inhibitor, and is an antibody (a type of human protein) designed to allow the body’s own immune system to seek out and destroy tumors. Giving sacituzumab govitecan alone or in combination with pembrolizumab may work better in delaying the worsening of HR+ / HER2- breast cancers that are also positive for PD-L1.

This trial may be offered at the following sites in the US (please check with center directly):

Dana-Farber Cancer Institute, Boston MA | Brigham and Women’s Hospital, Boston MA |

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Last status change to Active was on 2020-09-23.

For the complete listing see here: NCI-2020-07741

A Vaccine (MV-s-NAP) for the Treatment of Patients with Invasive Metastatic Breast Cancer

Phase I Trial of Intratumoral Administration of a Measles Virus Derivative Expressing the Helicobacter Pylori Neutrophil-Activating Protein (NAP) (MV-s-NAP) in Patients with Metastatic Breast Cancer

Phase I

This phase I trial investigates the side effects and best dose of using a modified measles virus, MV-s-NAP, in treating patients with invasive breast cancer that has spread to other places in the body (metastatic). Both the unmodified vaccination measles virus (MV-Edm) and this modified virus (MV-s-NAP) have been shown to multiply in and destroy breast cancer cells in the test tube and in research mice. MV-s-NAP has been altered by having an extra gene (piece of deoxyribonucleic acid [DNA]) so that virus can make a protein called helicobacter pylori neutrophil activating protein (NAP) which is normally expressed in inflammatory reactions. Monitoring blood, urine, tissue, and throat swab samples, and using imaging tests may help to determine whether MV-s-NAP has any impact on the amount of disease present in metastatic breast cancer patients.

This trial may be offered at the following sites in the US (please check with center directly):

Mayo Clinic in Rochester, Rochester MN |

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Last status change to Active was on 2020-09-23.

For the complete listing see here: NCI-2020-06009

DZD1516 in Combination With Trastuzumab and Capecitabine, or in Combination With T-DM1, in Patients With Metastatic HER2 Positive Breast Cancer

A Phase I, Open-Label, Multicenter Study to Investigate the Safety, Tolerability, Pharmacokinetics and Anti-tumor Activity of DZD1516 in Combination With Trastuzumab and Capecitabine, or DZD1516 in Combination With T-DM1, in Patients With Metastatic HER2 Positive (HER2+) Breast Cancer

Phase I

DZD1516 is an oral, blood brain barrier penetrable, selective HER2 tyrosine kinase inhibitor. This study is designed to evaluate the safety and tolerability of DZD1516 in patients with metastatic HER2 positive breast cancer who have progressed following prior therapy. This is the first time this drug has ever been tested in patients, and so it will help to understand what type of side effects may occur with the drug treatment. It will also measure the levels of drug in the body and assess its anti-cancer activity as monotherapy and in combination with trastuzumab and / or capecitabine, or in combination with T-DM1

This trial may be offered at the following sites in the US (please check with center directly):

UCLA / Jonsson Comprehensive Cancer Center, Los Angeles CA |

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Last status change to Active was on 2020-09-21.

For the complete listing see here: NCI-2020-06355

Rifaximin for the Treatment of Gastrointestinal Toxicities Related to Pertuzumab-Based Therapy in Patients with Stage I-III HER2 Positive Breast Cancer

Phase II Trial of Rifaximin in Patients with Early Stage HER2 Positive Breast Cancer with Gastrointestinal Toxicities Related to Pertuzumab-Based Therapy

Phase II

This phase II trial studies how well rifaximin works for the treatment of gastrointestinal toxicities related to pertuzumab-based therapy in patients with stage I-III HER2 positive breast cancer. Rifaximin may reduce the incidence and severity of pertuzumab induced gastrointestinal toxicities without interrupting or delaying the chemotherapy schedule.

This trial may be offered at the following sites in the US (please check with center directly):

Mayo Clinic in Florida, Jacksonville FL |

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Last status change to Active was on 2020-09-18.

For the complete listing see here: NCI-2020-00332

A Study of Tucatinib Plus Trastuzumab Deruxtecan in HER2+ Breast Cancer

A Single Arm, Open Label Phase 2 Study of Tucatinib in Combination With Trastuzumab Deruxtecan in Subjects With Previously Treated Unresectable Locally-Advanced or Metastatic HER2+ Breast Cancer

Phase II

This trial studies how well the drug tucatinib works when given with trastuzumab deruxtecan. It will also look at what side effects happen when these drugs are given together. A side effect is anything a drug does besides treating cancer. Participants in this trial have HER2-positive (HER2+) breast cancer that has either spread to other parts of the body (metastatic) or cannot be removed completely with surgery (unresectable). All participants will get both tucatinib and trastuzumab deruxtecan.

This trial may be offered at the following sites in the US (please check with center directly):

University of Alabama at Birmingham Cancer Center, Birmingham AL | City of Hope Comprehensive Cancer Center, Duarte CA | UCLA / Jonsson Comprehensive Cancer Center, Los Angeles CA | University of California San Francisco, San Francisco CA | University of Colorado Hospital, Aurora CO | Emory University Hospital / Winship Cancer Institute, Atlanta GA | Wake Forest University Health Sciences, Winston-Salem NC | M D Anderson Cancer Center, Houston TX | Fred Hutch / University of Washington Cancer Consortium, Seattle WA |

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Last status change to Active was on 2020-09-17.

For the complete listing see here: NCI-2020-08177

Cryoimmunotherapy and Pembrolizumab for the Treatment of Locally Advanced Unresectable or Cutaneous Metastatic Breast Cancer

Phase IB Pilot Study of Epicutaneous Cryoimmunotherapy Combined with Pembrolizumab for Cutaneous Metastatic Breast Cancer

Phase I

This phase IB trial studies the side effect of cryoimmunotherapy (cryotherapy, GM-CSF, and imiquimod) with pembrolizumab for the treatment of breast cancer that has spread to nearby tissue or lymph nodes (locally advanced) and cannot be removed by surgery (unresectable) or has spread to the skin (cutaneous metastatic). Cryotherapy is a procedure in which extremely cold liquid (liquid nitrogen) is used to freeze and destroy abnormal tissue. GM-CSF and imiquimod may help the immune system kill abnormal cells, including tumor cells. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving cryoimmunotherapy with pembrolizumab may work better in treating breast cancer that includes skin lesions.

This trial may be offered at the following sites in the US (please check with center directly):

Siteman Cancer Center at Washington University, Saint Louis MO |

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Last status change to Active was on 2020-09-14.

For the complete listing see here: NCI-2019-08917

Ribociclib in Treating Patients with Estrogen Receptor Positive Breast Cancer

Phase II Study of CDK 4 / 6 Inhibitor, LEE011 (Ribociclib), in Combination with Adjuvant Endocrine Therapy at Varying Duration for ER-Positive Breast Cancer (LEADER)

Phase II

This randomized phase II trial studies how well ribociclib works in treating patients with estrogen receptor positive breast cancer. Ribociclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

This trial may be offered at the following sites in the US (please check with center directly):

UCLA / Jonsson Comprehensive Cancer Center, Los Angeles CA | Beth Israel Deaconess Medical Center, Boston MA | Massachusetts General Hospital Cancer Center, Boston MA | Mass General / North Shore Cancer Center, Danvers MA | Newton-Wellesley Hospital, Newton MA |

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Last status change to Active was on 2020-09-03.

For the complete listing see here: NCI-2018-00166